Antiretroviral immune response and plasma interferon in different phases of chronic granulocytic leukemia

Béla Szabó, F. Tóth, Jolán Kiss, Atilla Kiss, Kálmán Rák

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Forty patients with chronic granulocytic leukemia (CGL) were tested for antibodies and lymphocytes reacting with gibbon ape leukemia virus (GaLV) and baboon endogenous virus (BaEV) antigens as well as for plasma interferon levels. Antibodies reacting with envelope antigens of GaLV and BaEV were found frequently and in high titers in patients with the quiescent phase of CGL but rarely and in low titers in the accelerated and blastic phase of the disease. Results of radio-immunoprecipitation studies were in concordance with those obtained in virus neutralization experiments. Cellular and humoral cytotoxic activity of blood plasma and lymphocyte samples against autologous tumor cells showed a similar phase-specific distribution. Most of these activities could be blocked by GaLV and BaEV gp70 antigens. Elevated plasma interferon (IFN)-α levels were found in the quiescent and accelerated phase of CGL, whereas no significant differences could be detected between IFN levels of patients with the blastic crisis of CGL and those of the control persons. Follow up studies of four patients confirmed this stage-specific distribution of antiretroviral immune and interferon response.

Original languageEnglish
Pages (from-to)311-323
Number of pages13
JournalLeukemia Research
Volume17
Issue number4
DOIs
Publication statusPublished - 1993

Fingerprint

Leukemia, Myeloid, Chronic Phase
Gibbon ape leukemia virus
Interferons
Papio
Viruses
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Antigens
Lymphocytes
Antibodies
Radio
Immunoprecipitation
Interferon-gamma
Neoplasms

Keywords

  • Antiretrovial antibodies
  • BaEV
  • cellular and humoral cytoxocity
  • CGL
  • GaLV
  • interferon

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Antiretroviral immune response and plasma interferon in different phases of chronic granulocytic leukemia. / Szabó, Béla; Tóth, F.; Kiss, Jolán; Kiss, Atilla; Rák, Kálmán.

In: Leukemia Research, Vol. 17, No. 4, 1993, p. 311-323.

Research output: Contribution to journalArticle

Szabó, Béla ; Tóth, F. ; Kiss, Jolán ; Kiss, Atilla ; Rák, Kálmán. / Antiretroviral immune response and plasma interferon in different phases of chronic granulocytic leukemia. In: Leukemia Research. 1993 ; Vol. 17, No. 4. pp. 311-323.
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