Antiproliferative Properties Against Human Breast, Cervical and Ovarian Cancer Cell Lines, and Antioxidant Capacity of Leaf Aqueous Ethanolic Extract from Cotinus coggygria Scop.

Z. Gospodinova, N. Bózsity, M. Nikolova, M. Krasteva, I. Zupkó

Research output: Contribution to journalArticle

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Abstract

Cotinus coggygria Scop. leaf aqueous ethanolic extract was examined for its in vitro antiproliferative and antioxidant activity. Antiproliferative effect was assessed on four human gynecological cancer cell lines: breast (MCF7, T47D), cervical (HeLa) and ovarian (A2780) and compared to the cell growth inhibitory effect on non-cancerous breast epithelial cell line MCF10A using MTT cell proliferation assay. Radical scavenging assay with DPPH was applied to evaluate antioxidant potential of the extract. The obtained results showed that the herb inhibited cell growth of all of the tested cancer cell lines and the highest was the cytostatic effect on A2780 cells with a half maximal inhibitory concentration (IC50) value of 30.8 μg/ml. For the other cell lines the IC50 values were in the range of 55-122.7 μg/ml. Additionally, the extract exerted considerably weaker reduction in cell proliferation of the non-cancerous cell line MCF10A compared to cancer cells, which indicates for antiproliferative selectivity. C. coggygria extract showed high free radical scavenging activity with an IC50 value of 11.2 μg/ml. The obtained data provide evidence for pharmacological potential of the tested extract and future more detailed studies concerning the molecular mechanisms of the anticancer effect of the herb are needed.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalActa Medica Bulgarica
Volume44
Issue number2
DOIs
Publication statusPublished - Oct 1 2017

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Anacardiaceae
Uterine Cervical Neoplasms
Ovarian Neoplasms
Antioxidants
Breast Neoplasms
Cell Line
Inhibitory Concentration 50
Breast
Cell Proliferation
Neoplasms
Cytostatic Agents
Growth
Free Radicals
Epithelial Cells
Pharmacology

Keywords

  • antioxidant activity
  • antiproliferative effect
  • cancer cell lines
  • cotinus coggygria Scop.

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Antiproliferative Properties Against Human Breast, Cervical and Ovarian Cancer Cell Lines, and Antioxidant Capacity of Leaf Aqueous Ethanolic Extract from Cotinus coggygria Scop. / Gospodinova, Z.; Bózsity, N.; Nikolova, M.; Krasteva, M.; Zupkó, I.

In: Acta Medica Bulgarica, Vol. 44, No. 2, 01.10.2017, p. 20-25.

Research output: Contribution to journalArticle

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