Antiproliferative Effect of a Novel 4,4’-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells

Anjali M. Prabhat, M. Lakshmi Kuppusamy, Balázs Bognár, Tamás Kálai, Kálmán Hideg, Periannan Kuppusamy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The synthesis and antiproliferative effect of a novel curcumin analog, 4,4’-disulfonyldiarylidenyl piperidone, are reported. The design of the molecule is based on the fusion of an antiproliferative segment, namely diarylidenyl piperidone (DAP), with N-hyroxypyrroline, which is known to metabolically convert to nitroxide and protect healthy cells. Cellular uptake, metabolic conversion, cytotoxicity and antiproliferative effect of the DAP derivative against HCT-116 human colon cancer cells have been determined. Based on cell viability and proliferation assays as well as western-blot analysis of major transcription factors and inhibitory proteins, it is determined that the DAP compound is cytotoxic by inhibiting cell survival and proliferation pathways. The findings may have important implications in the design and development of effective anticancer agents.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalCell Biochemistry and Biophysics
Volume77
Issue number1
DOIs
Publication statusPublished - Mar 15 2019

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Keywords

  • Colon cancer
  • Disulfonyldiarylidenyl piperidone
  • Nitroxide
  • Rreactive oxygen species

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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