Antiproliferative and antimicrobial properties of pure and encapsulated rutin

Corina Danciu, Iulia Andreea Pinzaru, Cristina Adriana Dehelean, Monica Hancianu, I. Zupkó, Dan Navolan, Monica Licker, Roxana Maria Ghiulai, Codruța Marinela Şoica

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4 Citations (Scopus)


Rutin, a polyphenolic natural compound is described in the literature for a wide range of biological activities. The study aims to test the antiproliferative potential and the antibacterial effect for pure rutin and its β cyclodextrin complexes. On one hand, the antiproliferative assays against A2780 (human ovarian cells), MDA-MB-231 (human breast cancer cells) and SiHa (cervical cancer cells) did not show any substantial inhibition of cell growth. On the other hand, the antimicrobial screening revealed that rutin presents positive effects against: Streptococcus pyogenes, Enterococcus faecalis, Bacillus cereus, Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli. A decreased, but detectable, activity was noticed for Staphylococcus aureus and Streptococcus pneumoniae. Incorporation in the ramified cyclodextrins had a mixed effect on the antibacterial activity, with increased, constant or decreased effect, depending on the strain. The study concludes that rutin can be reconsiderate as a natural active antibacterial agent, while modulation of its solubility by incorporation in β-cyclodextrins is debatable depending on the tested strain.

Original languageEnglish
Pages (from-to)302-308
Number of pages7
Issue number2
Publication statusPublished - Jan 1 2018


  • Antimicrobial
  • Antiproliferative
  • Cyclodextrin
  • Rutin

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Danciu, C., Pinzaru, I. A., Dehelean, C. A., Hancianu, M., Zupkó, I., Navolan, D., Licker, M., Ghiulai, R. M., & Şoica, C. M. (2018). Antiproliferative and antimicrobial properties of pure and encapsulated rutin. Farmacia, 66(2), 302-308.