Antiproliferative amaryllidaceae alkaloids isolated from the bulbs of Sprekelia formosissima and Hymenocallis x festalis

J. Hohmann, P. Forgó, J. Molnár, Krisztina Wolfard, A. Molnár, Theresia Thalhammer, I. Máthé, Derek Sharples

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Seven alkaloids were isolated from Sprekelia formosissima, and five from Hymenocallis x festalis. Tazettine, lycorine, haemanthidine and haemanthamine were evaluated for antiproliferative and multidrug resistance (mdr) reversing activity on mouse lymphoma cells. Lycorine, haemanthidine and haemanthamine displayed pronounced cell growth inhibitory activities against both drug-sensitive and drug-resistant cell lines, but did not significantly inhibit mdr-1 p-glycoprotein. Thus, the tested alkaloids are apparently not substrates for the mdr efflux pump. Assays for interactions with DNA and RNA revealed that the antiproliferative effects of lycorine and haemanthamine result from their complex formation with RNA.

Original languageEnglish
Pages (from-to)454-457
Number of pages4
JournalPlanta Medica
Volume68
Issue number5
DOIs
Publication statusPublished - 2002

Fingerprint

Amaryllidaceae Alkaloids
Hymenocallis
lycorine
Amaryllidaceae
multiple drug resistance
Multiple Drug Resistance
bulbs
alkaloids
Alkaloids
RNA
drugs
Cell growth
lymphoma
Pharmaceutical Preparations
transporters
glycoproteins
cell growth
Assays
Lymphoma
Glycoproteins

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antiproliferative amaryllidaceae alkaloids isolated from the bulbs of Sprekelia formosissima and Hymenocallis x festalis. / Hohmann, J.; Forgó, P.; Molnár, J.; Wolfard, Krisztina; Molnár, A.; Thalhammer, Theresia; Máthé, I.; Sharples, Derek.

In: Planta Medica, Vol. 68, No. 5, 2002, p. 454-457.

Research output: Contribution to journalArticle

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