Antiproliferative activity of polygonaceae species from the Carpathian Basin against human cancer cell lines

Ildikó Lajter, I. Zupkó, Judit Molnár, Gusztáv Jakab, Lajos Balogh, A. Vasas, J. Hohmann

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aqueous and organic extracts of 27 selected species from five genera (Fallopia, Oxyria, Persicaria, Polygonum and Rumex) of the family Polygonaceae occurring in the Carpathian Basin were screened in vitro for antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. A total of 196 n-hexane, chloroform, 50% methanol or water extracts of different plant parts were investigated. It was found that extracts of Polygonum hydropiper, Rumex acetosa, Rumex alpinus, Rumex aquaticus, Rumex scutatus and Rumex thyrsiflorus at 10 or 30 μg/mL demonstrated substantial cell growth inhibitory activity (at least 50% inhibition of cell proliferation) against one or more cell lines. R. acetosa and R. thyrsiflorus proved to be the most active and are considered worthy of activity-guided phytochemical investigations.

Original languageEnglish
Pages (from-to)77-85
Number of pages9
JournalPhytotherapy Research
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Polygonaceae
Rumex
Cell Line
Neoplasms
Polygonum
Adenocarcinoma
Plant Extracts
Phytochemicals
Chloroform
Cervix Uteri
Methanol
Squamous Cell Carcinoma
Breast
Epithelial Cells
Cell Proliferation

Keywords

  • antiproliferative activity
  • Fallopia
  • Persicaria
  • Polygonaceae
  • Polygonum
  • Rumex

ASJC Scopus subject areas

  • Pharmacology

Cite this

Antiproliferative activity of polygonaceae species from the Carpathian Basin against human cancer cell lines. / Lajter, Ildikó; Zupkó, I.; Molnár, Judit; Jakab, Gusztáv; Balogh, Lajos; Vasas, A.; Hohmann, J.

In: Phytotherapy Research, Vol. 27, No. 1, 01.2013, p. 77-85.

Research output: Contribution to journalArticle

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