Antiplasmid and carcinogenic molecular orbitals of benz[c]acridine and related compounds

J. Molnar, S. Petofi, T. Kurihara, H. Sakagami, N. Motohashi

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14 Citations (Scopus)

Abstract

Effect of K- and L- molecular orbital regions on expression of antiplasmid and carcinogenic activity was studied with various benz[c]acridine derivatives tricyclic compounds (acridine orange phenothiazines) and dibenzoazepine (imipramine). Antiplasmid compounds showed the out-of-phase of molecular orbital in the L-region. On the other hand mutagenic and carcinogenic compounds showed the out-of-phase in the L-region and their energy was accumulated in the K-region of the molecular orbitals. The present study suggests that the molecular orbitals responsible for the expression of antiplasmid and carcinogenic effects might be basically different.

Original languageEnglish
Pages (from-to)263-266
Number of pages4
JournalAnticancer research
Volume13
Issue number1
Publication statusPublished - Jan 1 1993

Keywords

  • Antiplasmid
  • Benz[c]acridine
  • Carcinogenic
  • Molecular orbitals

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Molnar, J., Petofi, S., Kurihara, T., Sakagami, H., & Motohashi, N. (1993). Antiplasmid and carcinogenic molecular orbitals of benz[c]acridine and related compounds. Anticancer research, 13(1), 263-266.