Antiplasmid and carcinogenic molecular orbitals of benz[c]acridine and related compounds

J. Molnár, S. Petofi, T. Kurihara, H. Sakagami, N. Motohashi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Effect of K- and L- molecular orbital regions on expression of antiplasmid and carcinogenic activity was studied with various benz[c]acridine derivatives tricyclic compounds (acridine orange phenothiazines) and dibenzoazepine (imipramine). Antiplasmid compounds showed the out-of-phase of molecular orbital in the L-region. On the other hand mutagenic and carcinogenic compounds showed the out-of-phase in the L-region and their energy was accumulated in the K-region of the molecular orbitals. The present study suggests that the molecular orbitals responsible for the expression of antiplasmid and carcinogenic effects might be basically different.

Original languageEnglish
Pages (from-to)263-266
Number of pages4
JournalAnticancer Research
Volume13
Issue number1
Publication statusPublished - 1993

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Phenothiazines
Acridine Orange
Imipramine
benz(c)acridine

Keywords

  • Antiplasmid
  • Benz[c]acridine
  • Carcinogenic
  • Molecular orbitals

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Molnár, J., Petofi, S., Kurihara, T., Sakagami, H., & Motohashi, N. (1993). Antiplasmid and carcinogenic molecular orbitals of benz[c]acridine and related compounds. Anticancer Research, 13(1), 263-266.

Antiplasmid and carcinogenic molecular orbitals of benz[c]acridine and related compounds. / Molnár, J.; Petofi, S.; Kurihara, T.; Sakagami, H.; Motohashi, N.

In: Anticancer Research, Vol. 13, No. 1, 1993, p. 263-266.

Research output: Contribution to journalArticle

Molnár, J, Petofi, S, Kurihara, T, Sakagami, H & Motohashi, N 1993, 'Antiplasmid and carcinogenic molecular orbitals of benz[c]acridine and related compounds', Anticancer Research, vol. 13, no. 1, pp. 263-266.
Molnár, J. ; Petofi, S. ; Kurihara, T. ; Sakagami, H. ; Motohashi, N. / Antiplasmid and carcinogenic molecular orbitals of benz[c]acridine and related compounds. In: Anticancer Research. 1993 ; Vol. 13, No. 1. pp. 263-266.
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