Effect of K- and L- molecular orbital regions on expression of antiplasmid and carcinogenic activity was studied with various benz[c]acridine derivatives tricyclic compounds (acridine orange phenothiazines) and dibenzoazepine (imipramine). Antiplasmid compounds showed the out-of-phase of molecular orbital in the L-region. On the other hand mutagenic and carcinogenic compounds showed the out-of-phase in the L-region and their energy was accumulated in the K-region of the molecular orbitals. The present study suggests that the molecular orbitals responsible for the expression of antiplasmid and carcinogenic effects might be basically different.
|Number of pages||4|
|Publication status||Published - Jan 1 1993|
- Molecular orbitals
ASJC Scopus subject areas
- Cancer Research