Antiplasmid activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines

N. Motohashi, H. Sakagami, T. Kurihara, K. Csuri, J. Molnar

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Various synthetic derivatives of phenothiazines, benzo[a]phenothiazines and benz[c]acridines were compared for their abilities to induce antiplasmid activity against E. coli F'lac plasmid. Several phenothiazine derivatives were much more potent in antiplasmid activity than benzo[a]phenothiazine- or benz[c]acridine derivatives. Their antiplasmid activity seemed to be enhanced by Cl- or CF3- substitution at 2 C atom, and modified by the side chain length and charge at the L-region of the molecules, as well as by hydrophilicity.

Original languageEnglish
Pages (from-to)135-139
Number of pages5
JournalAnticancer research
Volume12
Issue number1
Publication statusPublished - Jan 1 1992

Keywords

  • Antiplasmid activity
  • Benz[c]acridines
  • Benzo[a]phenothiazines
  • Phenothiazines

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Motohashi, N., Sakagami, H., Kurihara, T., Csuri, K., & Molnar, J. (1992). Antiplasmid activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines. Anticancer research, 12(1), 135-139.