Antiplasmid activity

loss of bacterial resistance to antibiotics.

J. Molnár, S. Földeák, M. J. Nakamura, H. Rausch, K. Domonkos, M. Szabó

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The antiplasmid activity of tricyclic compounds, e.g. phenothiazines, dibenzoazepines, dibenzocykloheptene derivatives and some stereoisomers, was shown on E. coli in vitro. Some ring-substituted phenothiazine and cannabis derivatives had only an antibacterial effect. Promethazine, a selected phenothiazine, cured antibiotic resistance and lactose fermentation of E.coli, tumour inducing ability of Agrobacterium tumefaciens and nodule formation of Rhizobium meliloti. Plasmids of different E.coli strains were eliminated with varying frequency. The antiplasmid activity of the compounds can be due to the increased membrane permeability. Inhibition of DNA gyrase and complex formation with the supercoiled form of plasmid DNA can lead to the cessation of plasmid replication in the bacterial cells. In addition, in vivo plasmid curing was demonstrated at a low frequency.

Original languageEnglish
Pages (from-to)24-31
Number of pages8
JournalAPMIS. Supplementum
Volume30
Publication statusPublished - 1992

Fingerprint

Bacterial Drug Resistance
Plasmids
Escherichia coli
DNA Gyrase
Promethazine
Sinorhizobium meliloti
Phenothiazines
Agrobacterium tumefaciens
Stereoisomerism
Cannabis
Lactose
Microbial Drug Resistance
Fermentation
Permeability
Membranes
DNA
Neoplasms
phenothiazine

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)
  • Pathology and Forensic Medicine

Cite this

Molnár, J., Földeák, S., Nakamura, M. J., Rausch, H., Domonkos, K., & Szabó, M. (1992). Antiplasmid activity: loss of bacterial resistance to antibiotics. APMIS. Supplementum, 30, 24-31.

Antiplasmid activity : loss of bacterial resistance to antibiotics. / Molnár, J.; Földeák, S.; Nakamura, M. J.; Rausch, H.; Domonkos, K.; Szabó, M.

In: APMIS. Supplementum, Vol. 30, 1992, p. 24-31.

Research output: Contribution to journalArticle

Molnár, J, Földeák, S, Nakamura, MJ, Rausch, H, Domonkos, K & Szabó, M 1992, 'Antiplasmid activity: loss of bacterial resistance to antibiotics.', APMIS. Supplementum, vol. 30, pp. 24-31.
Molnár J, Földeák S, Nakamura MJ, Rausch H, Domonkos K, Szabó M. Antiplasmid activity: loss of bacterial resistance to antibiotics. APMIS. Supplementum. 1992;30:24-31.
Molnár, J. ; Földeák, S. ; Nakamura, M. J. ; Rausch, H. ; Domonkos, K. ; Szabó, M. / Antiplasmid activity : loss of bacterial resistance to antibiotics. In: APMIS. Supplementum. 1992 ; Vol. 30. pp. 24-31.
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