Antiphospholipid antibodies in acute coronary syndrome

K. Veres, G. Lakos, A. Kerényi, Z. Szekanecz, G. Szegedi, Y. Shoenfeld, Pál Soltész

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Abstract

Antiphospholipid (aPL) antibodies entailing anticardiolipin (aCL) and anti-β2 glycoprotein I (anti-β2GPI) antibodies may be involved in a number of vascular diseases including coronary artery diseases (CAD) or stroke. Here we assessed the presence of aPL antibodies in acute coronary syndrome (ACS). The frequency of anti-β2GPI antibodies was significantly higher (14.4%) in ACS in comparison to control healthy subjects (2%). In addition, serum concentrations of anti- β2GPI antibodies were also increased in ACS. Anti-β2GPI antibodies of the IgA isotype might be the most relevant for the onset and outcome of ACS. Regarding subclasses of ACS, anti-β2GPI IgA antibodies were elevated in unstable angina (UA) and myocardial infarction with ST elevation (STEMI), but not in myocardial infarction without ST elevation (NSTEMI). The involvement of anti-β2GPI antibodies in ACS was more pronounced in men than women, and in younger rather than older patients. Finally, anti- β2GPI antibodies in ACS were associated with previous stroke, but not with hypertension or previous myocardial infarction. Thus, anti-β2GPI antibodies may be involved in the thrombotic events underlying ACS.

Original languageEnglish
Pages (from-to)423-427
Number of pages5
JournalLupus
Volume13
Issue number6
DOIs
Publication statusPublished - Jul 28 2004

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Keywords

  • Acute coronary syndrome
  • Antiphospholipid antibody
  • Coronary artery disease
  • Myocardial infarction
  • β glycoprotein I

ASJC Scopus subject areas

  • Rheumatology

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