Antioxidants in organophosphorus compounds poisoning

Syed M. Nurulain, Peter Szegi, Kornèlia Tekes, Syed Nh Naqvi

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Oxidative stress has recently been implicated as a factor in the mortality and morbidity induced by organophosphorus (OP) compound poisoning. An overwhelming number of research papers are based on studying at the cellular and organ level. Such studies have concluded that antioxidants can be used as an adjunct compound in the treatment of both chronic as well as acute OP poisoning. Still, the role of antioxidants in reducing the mortality and morbidity induced by OP compounds has scarcely been verifi ed, as well as their role as adjunct treatment compounds for both structurally and functionally different OP compounds. The present review of the literature was undertaken to establish the role of antioxidants in survival studies following acute exposure to OP compounds. The review found no substantial evidence that antioxidants demonstrate any positive effect following extremely toxic poisoning. However, for a more comprehensive and rational conclusion, further research needs to be conducted.

Original languageEnglish
Pages (from-to)169-177
Number of pages9
JournalArhiv za Higijenu Rada i Toksikologiju
Volume64
Issue number1
DOIs
Publication statusPublished - 2013

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Keywords

  • Acute poisoning
  • Oxidative stress
  • Survival study

ASJC Scopus subject areas

  • Toxicology
  • Public Health, Environmental and Occupational Health

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