Antioxidant status of patients with well controlled type I diabetes

E. Szaleczky, J. Prechl, P. Pusztai, A. Rosta, J. Fehér, A. Somogyi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

17 non-diabetic subjects and 11 patients with type I diabetes - matched in age and BMI were studied in order to evaluate the effects of well controlled diabetes on antioxidant status. Mean duration of diabetes was 10 years; a mean HbA1c value of 6 .06 0.48% implied a good blood glucose control. All the diabetics subjects were on intensive insulin therapy and had no renal complications. Atherogen index (total cholesterol/HDL cholesterol) was practically identical in the two groups (3.05 vs 156 μM), but the difference was not significant (p=0.11). Antioxidant enzyme activities (erythrocyte superoxide dismutase and catalase, whole blood glutathione peroxidase) did not differ in the two groups. Similarly Total Antioxidant Status - a measure of overall antioxidant defense in plasma - and TBARS concentrations were not statistically different in controls and diabetics. We assume that type I diabetes, when blood glucose is strictly controlled by intensive insulin therapy, is not accompanied by changes in the prooxidant - antioxidant balance.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalMedical Science Monitor
Volume3
Issue number2
Publication statusPublished - 1997

Fingerprint

Type 1 Diabetes Mellitus
Antioxidants
Blood Glucose
Insulin
Glutathione Peroxidase
Catalase
HDL Cholesterol
Superoxide Dismutase
Erythrocytes
Cholesterol
Kidney
Enzymes
Therapeutics

Keywords

  • Antioxides
  • Catalase
  • Diabetes mellitus
  • Glutaxione peroxidase
  • Intensive insulin therapy
  • Lipid peroxides
  • Superoxide dismutase
  • Total antioxidant status

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Antioxidant status of patients with well controlled type I diabetes. / Szaleczky, E.; Prechl, J.; Pusztai, P.; Rosta, A.; Fehér, J.; Somogyi, A.

In: Medical Science Monitor, Vol. 3, No. 2, 1997, p. 163-166.

Research output: Contribution to journalArticle

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AU - Fehér, J.

AU - Somogyi, A.

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