Antioxidant properties of DI- and polyamines

B. Matkovics, V. Kecskemeti, Sz I. Varga, Z. Novak, Zs Kertesz

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1. 1. One diamine, putrescine and two polyamines, spermidine and spermidine (PAs) of different concentrations, were processed through antioxidant systems in order to study their antioxidant effects. The systems investigated were as follows. 2. 2. "Oxidative stress" was induced in RBCs to investigate filtration parameters, the effect of reduced glutathione (GSH) and the change in lipid peroxidation (LP) superoxide dismutase (SOD) activities. 3. 3. Initiated LP-decreasing characteristics of the substances were studied in pig brain homogenate. 4. 4. The LP-decreasing effect of these PAs were studied in guinea-pig heart tissue homogenate perfused with Tyrode solution, stimulated, and then perfused by the Langdorff method. 5. 5. In all three tests, the antioxidant characteristics of PAs were unambiguously proved.

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Issue number3
Publication statusPublished - Mar 1993


ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology

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