Antioxidant properties of 8.O.4′-neolignans

K. Kónya, Z. Varga, S. Antus

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A series of naturally occurring 8.O.4′-neolignans (1a-d, 1g, 2g, 2h) and their analogues (1e-f, 1h, 1i, 2a-f, 2i) have been synthesized in racemic form starting from commercially available phenols, such as eugenol, isoeugenol and 4-allyl-2,6-dimethoxyphenol and from aromatic aldehydes, such as piperonal, veratraldehyde and 3,4,5-trimethoxybenzaldehyde. The inhibitory activity of these compounds on superoxide anion (O2-) release by human polymorphonuclear leukocytes (PMNLs) was tested and the structure-activity relationship was also studied.

Original languageEnglish
Pages (from-to)454-459
Number of pages6
JournalPhytomedicine
Volume8
Issue number6
Publication statusPublished - 2001

Fingerprint

isoeugenol
Eugenol
Lignans
eugenol
Phenols
lignans
structure-activity relationships
Structure-Activity Relationship
Aldehydes
Superoxides
phenols
superoxide anion
aldehydes
aromatic compounds
neutrophils
Neutrophils
Antioxidants
antioxidants
4-allyl-2,6-dimethoxyphenol
piperonal

Keywords

  • 8.O.4′-neolignans
  • Antioxidant activity
  • Superoxide anion
  • Synthesis

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antioxidant properties of 8.O.4′-neolignans. / Kónya, K.; Varga, Z.; Antus, S.

In: Phytomedicine, Vol. 8, No. 6, 2001, p. 454-459.

Research output: Contribution to journalArticle

Kónya, K. ; Varga, Z. ; Antus, S. / Antioxidant properties of 8.O.4′-neolignans. In: Phytomedicine. 2001 ; Vol. 8, No. 6. pp. 454-459.
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