Antioxidant properties of 8.O.4′-neolignans

K. Kónya, Zs Varga, S. Antus

Research output: Contribution to journalArticle

20 Citations (Scopus)


A series of naturally occurring 8.O.4′-neolignans (1a-d, 1g, 2g, 2h) and their analogues (1e-f, 1h, 1i, 2a-f, 2i) have been synthesized in racemic form starting from commercially available phenols, such as eugenol, isoeugenol and 4-allyl-2,6-dimethoxyphenol and from aromatic aldehydes, such as piperonal, veratraldehyde and 3,4,5-trimethoxybenzaldehyde. The inhibitory activity of these compounds on superoxide anion (O2-) release by human polymorphonuclear leukocytes (PMNLs) was tested and the structure-activity relationship was also studied.

Original languageEnglish
Pages (from-to)454-459
Number of pages6
Issue number6
Publication statusPublished - Jan 1 2001


  • 8.O.4′-neolignans
  • Antioxidant activity
  • Superoxide anion
  • Synthesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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