Antioxidant parameters and ageing in some animal species

T. Gaál, B. K. Speake, M. Mézes, R. C. Noble, P. F. Surai, P. Vajdovich

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Connection between ageing and some tissue antioxidant parameters have been studied in four experiments on different animal species. Prenatal studies on the developing chick embryos showed discrepancies between the lipid-rich liver and brain antioxidant defence. In the liver, high levels of reduced glutathione (GSH), vitamins A and E and high activities of the antioxidant enzymes glutathione peroxidase (GPX) and superoxide dismutase (SOD) were found whereas brain expressed a high vitamin C concentration. In newborn healthy calves during the first two days of life, atmospheric oxygen tension did not cause either increased lipid peroxidation as reflected in a high malondialdehyde (MDA) level or any changes in GSH, GPX, SOD and catalase (CAT) activities in red blood cells (RBC). Plasma vitamin E and carotene concentrations also did not change. In growing healthy calves during two months after birth increasing MDA, decreasing GSH, GPX and CAT are leading features, whereas plasma vitamin E and carotene concentrations significantly increased. In young (1-year-old) and old (9-year-old) dogs RBC results showed significant differences with the highest MDA and lowest GSH levels in the old males. Activity of GPX and SOD was higher in old dogs than in the young ones, especially in the females.

Original languageEnglish
Pages (from-to)208-213
Number of pages6
JournalComparative Haematology International
Volume6
Issue number4
DOIs
Publication statusPublished - 1996

Fingerprint

Glutathione Peroxidase
Antioxidants
Malondialdehyde
Vitamin E
Superoxide Dismutase
Carotenoids
Catalase
Erythrocytes
Dogs
Liver
Brain
Chick Embryo
Vitamin A
Lipid Peroxidation
Ascorbic Acid
Glutathione
Parturition
Oxygen
Lipids
Enzymes

Keywords

  • Ageing
  • Antioxidants
  • Calf
  • Chick
  • Dog
  • Lipidperoxidation

ASJC Scopus subject areas

  • Hematology

Cite this

Gaál, T., Speake, B. K., Mézes, M., Noble, R. C., Surai, P. F., & Vajdovich, P. (1996). Antioxidant parameters and ageing in some animal species. Comparative Haematology International, 6(4), 208-213. https://doi.org/10.1007/BF00378112

Antioxidant parameters and ageing in some animal species. / Gaál, T.; Speake, B. K.; Mézes, M.; Noble, R. C.; Surai, P. F.; Vajdovich, P.

In: Comparative Haematology International, Vol. 6, No. 4, 1996, p. 208-213.

Research output: Contribution to journalArticle

Gaál, T, Speake, BK, Mézes, M, Noble, RC, Surai, PF & Vajdovich, P 1996, 'Antioxidant parameters and ageing in some animal species', Comparative Haematology International, vol. 6, no. 4, pp. 208-213. https://doi.org/10.1007/BF00378112
Gaál, T. ; Speake, B. K. ; Mézes, M. ; Noble, R. C. ; Surai, P. F. ; Vajdovich, P. / Antioxidant parameters and ageing in some animal species. In: Comparative Haematology International. 1996 ; Vol. 6, No. 4. pp. 208-213.
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