Antioxidant enzyme activities are decreased in preterm infants and in neonates born via caesarean section

George D. Georgeson, Barnabás J. Szony, Károly Streitman, Ilona Sz Varga, Attila Kovács, László Kovács, Aranka László

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103 Citations (Scopus)


Objectives: To investigate the antioxidant defense potential of human neonates according to gestational age and mode of delivery. Study design: Four study groups were established, full-term normal spontaneous vaginal delivery (FT-NSVD, n=24), full-term caesarean section (FT-CS, n=19), preterm normal spontaneous vaginal delivery (PT-NSVD, n=15) preterm caesarean section (PT-CS, n=21). The activity of catalase (CAT), glutathion peroxidase (GPX), Cu/Zn superoxide dismutase (Cu/Zn-SOD) were determined from cord blood. Statistical analysis was made by ANOVA. Results: CAT activity was significantly higher in full-term than in preterm newborns. In both the categories, neonates born via caesarean section had significantly lower CAT activities. GPX activity was significantly higher in the FT-NSVD group than in any other group. Cu/Zn-SOD activity was significantly higher in full-term neonates than in preterms and no difference was found related to the mode of delivery. Conclusions: Prematurity and caesarean section may cause a deficiency of antioxidant defense in human newborn.

Original languageEnglish
Pages (from-to)136-139
Number of pages4
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number2
Publication statusPublished - Jul 10 2002



  • Antioxidant enzymes
  • Caesarean section
  • Full-term neonate
  • Neonate
  • Preterm newborn

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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