Antineoplastic potential of mycotoxins

I. Pócsi, Gábor Király, G. Bánfalvi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Fungal toxins are secondary metabolites, in which many of them were mycotoxins, affecting eukaryotic cells with a broad range of structural and functional variety contributing to the multitude of their classification. This refers to the harmful genotoxic (mutagenic, teratogenic, and carcinogenic) effects of mycotoxins on the one hand, and their cytocidic and antineoplastic properties on the other hand. This "double edged sword" effect could be utilized against the spread of tumors in older patients when the survival is much more important than the mutagenic side effects. To decide which fungal toxins could be used as combined cytotoxic and antimetastatic agents, mycotoxins were divided into three categories: (a) highly genotoxic (mutagenic, teratogenic, and carcinogenic), (b) adversely toxic, and (c) antitumorigenic agents. Highly cytotoxic mycotoxins with tolerable side effects, combined with an antineoplastic character, could be potential candidates against metastasis. From the structure-function relationship of antimetastatic mycotoxins, only general conclusions have been drawn. The presence of ring structures containing heteroatoms, functional groups, and the cumulative presence of oxygen atoms contributed to the oxidative stress and cytotoxicity of mycotoxins. The preselection of mycotoxins excluded category (a), and only the categories (b) and (c) were considered to be potential agents against the metastatic spread of abdominal tumors in rodent metastatic tumor experiments.

Original languageEnglish
Pages (from-to)297-307
Number of pages11
JournalActa Microbiologica et Immunologica Hungarica
Volume65
Issue number3
DOIs
Publication statusPublished - Aug 1 2018

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Mycotoxins
Antineoplastic Agents
Neoplasms
Poisons
Cytotoxins
Eukaryotic Cells
Rodentia
Oxidative Stress
Oxygen
Neoplasm Metastasis
Survival

Keywords

  • Antitumor agents
  • Carcinogens
  • Metastatic connection
  • Structure-function relationship

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Antineoplastic potential of mycotoxins. / Pócsi, I.; Király, Gábor; Bánfalvi, G.

In: Acta Microbiologica et Immunologica Hungarica, Vol. 65, No. 3, 01.08.2018, p. 297-307.

Research output: Contribution to journalArticle

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