Antimutagenicity of phenothiazine-metal co-ordination complexes in chemically induced mutagenesis

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Phenothiazines are heterocyclic organic compounds in which nitrogen and sulfur are incorporated in the tricyclic system, and are known to have anitmutagenic activity by shielding DNA-base pairs. Inorganic metals have also been intensively studied for DNA-adduct formation as potential anticancer agents. Phenothiazine, promethazine, promazine and chlopromazine were complexed either with copper, palladium or gold. The antimutagenicity of twelve phenothiaizine-metal complexes, four phenothiazines and three inorganic metals was examined on Salmonella typhimurium TA98 strain treated with a strain-specific, direct-acting mutagen, 4-nitro-o-phenylene-diamine, and the ligand-DNA interaction was analyzed by ultraviolet (UV) spectrophotometry. Phenothoazine-metal coordination complexes generally increased their antimutagenic activity, compare to their parent compounds, and the enhanced antimutagenicity was attributed to their interaction with DNA as evidenced by the spectra.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalAnticancer Research
Volume17
Issue number1 A
Publication statusPublished - 1997

Fingerprint

Coordination Complexes
Mutagenesis
Phenothiazines
Metals
DNA
Promazine
Ultraviolet Spectrophotometry
Promethazine
Heterocyclic Compounds
Diamines
DNA Adducts
Mutagens
Palladium
Salmonella typhimurium
Sulfur
Base Pairing
Gold
Antineoplastic Agents
Copper
Nitrogen

Keywords

  • Antimutagenicity
  • Metal-complex and chemical mutagenesis
  • Phenothiazines

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Antimutagenicity of phenothiazine-metal co-ordination complexes in chemically induced mutagenesis. / Tanaka, M.; Molnár, J.; Kidd, Sue.

In: Anticancer Research, Vol. 17, No. 1 A, 1997, p. 381-385.

Research output: Contribution to journalArticle

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