Antimutagenicity of benzo[a]phenothiazines in chemically induced mutagenesis

Masaru Tanaka, Kornélia Wayda, Joseph Molnár, Noboru Motohashi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Antipsychotic phenothiazines are known to have antimutagenic activities. The antimutagenicity of seven benzo[a]phenothiazines was screened against Salmonella typhimurium strain TA 98 treated with 4-nitro-o-phenylenediamine (4-NPD) which is a specific mutagen to this strain, and was compared to the antimutagenic activity of chlorpmmazine, a 2-chlorphenothiazine derivative which has been shown to be the most effective mutagen inhibitor in the model. Benzo[a]phenothiazines are variously substituted by methyl-, oxo- and/or hydroxyl-substituent(s) at 5, 6, 9 and/or 10 position (s). 9-Methyl-12H-benzo[a]phenothiazine [3] reduced the 4-NPD induced mutation by 30 percent, being a more potent antimutagenic agent than chlorpmmazine. The study of antimutagenicity is of great interest in the development of cancer chemopreventive agents which hull cancer progression in multistage carcinogenesis, where successive mutation sequences are required to evolve into full-fledged metastatic cancer.

Original languageEnglish
Pages (from-to)3625-3628
Number of pages4
JournalAnticancer research
Volume16
Issue number6 B
Publication statusPublished - Dec 1 1996

Keywords

  • Antimutagenicity
  • Phenothiazines

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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