Antimicrobial Silver-Polyethyleneimine-Polylactic Acid Polymer Composite Film for Coating Methacrylate-Based Denture Surfaces

Zoltán Géczi, P. Hermann, L. Kőhidai, Orsolya Láng, Zsófia Køhidai, T. Mészáros, Attila Barócsi, Sándor Lenk, T. Zelles

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To prepare an antimicrobial polymer composite composed of silver- (Ag-) polyethyleneimine- (PEI-) polylactic acid (PLA) in chloroform, for coating the mucosal surfaces of methacrylate-based dentures as a prospective therapy for denture stomatitis. The water-insoluble, tightly bound, hard, micrometre-thin, and colourless film exerts its effects by direct contact with the pathogens and via the active constituents (Ag, PEI, and Ag-PEI) released slowly into the mucosa's salivary layer. Silver and PEI were blended at 140°C, then bound to PLA. The Ag-PEI complex was characterised by dynamic light scattering and transmission electron microscopy, and the Ag-PEI-PLA composite was examined by atomic force microscopy and micro-computed tomography. The characteristic was measured by atomic force microscopy (AFM) and micro-computed tomography (micro-CT). The quantity of water-soluble Ag-PEI complex released from the composite film was measured with gravimetry. The cellular physiological effects were analysed by impedimetry and computer-based morphometry using human gingival epithelial cells. A real-time cell proliferation assay revealed moderate toxic effects of Ag-PEI on the epithelium. The viscous Ag-PEI-PLA solution produced could be applied as a thin film on methacrylate surfaces. Active antimicrobial components (Ag, PEI, and Ag-PEI) were released from the hard, tightly bound Ag-PEI-PLA coating. This study's findings verified the applicability of the antimicrobial Ag-PEI-PLA composite for coating the inner surfaces of acrylate dentures. Owing to the well-known antimicrobial effects of silver and PEI and the supplementary effects of chloroform, this composite provides a new therapeutic method for denture stomatitis that can be easily performed by dentists.

Original languageEnglish
Article number1048734
JournalJournal of Nanomaterials
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

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Polyethyleneimine
Dental prostheses
Polyetherimides
Methacrylates
Composite films
Silver
Polymer films
Coatings
Acids
Composite materials
Chloroform
Chlorine compounds
Tomography
Atomic force microscopy
Water
Gravimetric analysis
Poisons
Cell proliferation
Pathogens
Dynamic light scattering

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Antimicrobial Silver-Polyethyleneimine-Polylactic Acid Polymer Composite Film for Coating Methacrylate-Based Denture Surfaces. / Géczi, Zoltán; Hermann, P.; Kőhidai, L.; Láng, Orsolya; Køhidai, Zsófia; Mészáros, T.; Barócsi, Attila; Lenk, Sándor; Zelles, T.

In: Journal of Nanomaterials, Vol. 2018, 1048734, 01.01.2018.

Research output: Contribution to journalArticle

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