Antimicrobial drug use and resistance in Europe

Nienke Van De Sande-Bruinsma, Hajo Grundmann, Didier Verloo, Edine Tiemersma, Jos Monen, Herman Goossens, Matus Ferech, H. Mittermayer, S. Metz, W. Koller, E. Hendrickx, B. Markova, A. Tambic-Andrasevic, Igor Francetic, S. Kalenic, D. Bagatzouni, P. Dvorak, P. Urbaskova, D. Monnet, A. Anker NielsenP. Naaber, P. Huovinen, P. Paakkari, O. Lyytikainen, A. Nissinen, P. Maugendre, D. Guillemot, B. Coignard, V. Jarlier, W. Kern, H. Schroeder, W. Witte, K. Heckenbach, H. Giamarellou, A. Antoniadou, A. Tsakris, A. Vatopoulos, G. Ternák, M. Füzi, K. Kristinsson, E. Smyth, R. Cunney, D. Igoe, O. Murphy, R. Raz, G. Cornaglia, A. Pantosti, P. D'Ancona, S. Berzina, A. Balode, R. Valenteliene, J. Miciulevicience, R. Hemmer, M. Bruch, M. Borg, P. Zarb, R. Janknegt, M. Filius, H. De Neeling, E. Tiemermsa, J. Degener, H. Salvesen Blix, A. Hoiby, G. Simonsen, W. Hryniewicz, P. Grzesiowski, L. Caldeira, M. Canica, I. Codita, V. Foltan, T. Tesar, L. Langsadl, M. Cizman, M. Mueller-Premru, J. Kolman, J. Campos, F. Baquero, O. Cars, G. Skoog, B. Liljequist, G. Kahlmeter, S. Unal, D. Gür, P. Davey, A. Johnson, R. Hill, H. Hughes, M. Coyne

Research output: Contribution to journalArticle

288 Citations (Scopus)

Abstract

Our study confronts the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 2000-2005 and explores whether the notion that antimicrobial drug use determines resistance can be supported by surveillance data at national aggregation levels. The data obtained from the European Surveillance of Antimicrobial Consumption and the European Antimicrobial Resistance Surveillance System suggest that variation of consumption coincides with the occurrence of resistance at the country level. Linear regression analysis showed that the association between antimicrobial drug use and resistance was specific and robust for 2 of 3 compound pathogen combinations, stable over time, but not sensitive enough to explain all of the observed variations. Ecologic studies based on routine surveillance data indicate a relation between use and resistance and support interventions designed to reduce antimicrobial drug consumption at a national level in Europe.

Original languageEnglish
Pages (from-to)1722-1730
Number of pages9
JournalEmerging Infectious Diseases
Volume14
Issue number11
DOIs
Publication statusPublished - Nov 2008

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Microbial Drug Resistance
Ambulatory Care
Anti-Infective Agents
Streptococcus pneumoniae
Pharmaceutical Preparations
Linear Models
Regression Analysis
Escherichia coli

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Van De Sande-Bruinsma, N., Grundmann, H., Verloo, D., Tiemersma, E., Monen, J., Goossens, H., ... Coyne, M. (2008). Antimicrobial drug use and resistance in Europe. Emerging Infectious Diseases, 14(11), 1722-1730. https://doi.org/10.3201/eid1411.070467

Antimicrobial drug use and resistance in Europe. / Van De Sande-Bruinsma, Nienke; Grundmann, Hajo; Verloo, Didier; Tiemersma, Edine; Monen, Jos; Goossens, Herman; Ferech, Matus; Mittermayer, H.; Metz, S.; Koller, W.; Hendrickx, E.; Markova, B.; Tambic-Andrasevic, A.; Francetic, Igor; Kalenic, S.; Bagatzouni, D.; Dvorak, P.; Urbaskova, P.; Monnet, D.; Anker Nielsen, A.; Naaber, P.; Huovinen, P.; Paakkari, P.; Lyytikainen, O.; Nissinen, A.; Maugendre, P.; Guillemot, D.; Coignard, B.; Jarlier, V.; Kern, W.; Schroeder, H.; Witte, W.; Heckenbach, K.; Giamarellou, H.; Antoniadou, A.; Tsakris, A.; Vatopoulos, A.; Ternák, G.; Füzi, M.; Kristinsson, K.; Smyth, E.; Cunney, R.; Igoe, D.; Murphy, O.; Raz, R.; Cornaglia, G.; Pantosti, A.; D'Ancona, P.; Berzina, S.; Balode, A.; Valenteliene, R.; Miciulevicience, J.; Hemmer, R.; Bruch, M.; Borg, M.; Zarb, P.; Janknegt, R.; Filius, M.; De Neeling, H.; Tiemermsa, E.; Degener, J.; Salvesen Blix, H.; Hoiby, A.; Simonsen, G.; Hryniewicz, W.; Grzesiowski, P.; Caldeira, L.; Canica, M.; Codita, I.; Foltan, V.; Tesar, T.; Langsadl, L.; Cizman, M.; Mueller-Premru, M.; Kolman, J.; Campos, J.; Baquero, F.; Cars, O.; Skoog, G.; Liljequist, B.; Kahlmeter, G.; Unal, S.; Gür, D.; Davey, P.; Johnson, A.; Hill, R.; Hughes, H.; Coyne, M.

In: Emerging Infectious Diseases, Vol. 14, No. 11, 11.2008, p. 1722-1730.

Research output: Contribution to journalArticle

Van De Sande-Bruinsma, N, Grundmann, H, Verloo, D, Tiemersma, E, Monen, J, Goossens, H, Ferech, M, Mittermayer, H, Metz, S, Koller, W, Hendrickx, E, Markova, B, Tambic-Andrasevic, A, Francetic, I, Kalenic, S, Bagatzouni, D, Dvorak, P, Urbaskova, P, Monnet, D, Anker Nielsen, A, Naaber, P, Huovinen, P, Paakkari, P, Lyytikainen, O, Nissinen, A, Maugendre, P, Guillemot, D, Coignard, B, Jarlier, V, Kern, W, Schroeder, H, Witte, W, Heckenbach, K, Giamarellou, H, Antoniadou, A, Tsakris, A, Vatopoulos, A, Ternák, G, Füzi, M, Kristinsson, K, Smyth, E, Cunney, R, Igoe, D, Murphy, O, Raz, R, Cornaglia, G, Pantosti, A, D'Ancona, P, Berzina, S, Balode, A, Valenteliene, R, Miciulevicience, J, Hemmer, R, Bruch, M, Borg, M, Zarb, P, Janknegt, R, Filius, M, De Neeling, H, Tiemermsa, E, Degener, J, Salvesen Blix, H, Hoiby, A, Simonsen, G, Hryniewicz, W, Grzesiowski, P, Caldeira, L, Canica, M, Codita, I, Foltan, V, Tesar, T, Langsadl, L, Cizman, M, Mueller-Premru, M, Kolman, J, Campos, J, Baquero, F, Cars, O, Skoog, G, Liljequist, B, Kahlmeter, G, Unal, S, Gür, D, Davey, P, Johnson, A, Hill, R, Hughes, H & Coyne, M 2008, 'Antimicrobial drug use and resistance in Europe', Emerging Infectious Diseases, vol. 14, no. 11, pp. 1722-1730. https://doi.org/10.3201/eid1411.070467
Van De Sande-Bruinsma N, Grundmann H, Verloo D, Tiemersma E, Monen J, Goossens H et al. Antimicrobial drug use and resistance in Europe. Emerging Infectious Diseases. 2008 Nov;14(11):1722-1730. https://doi.org/10.3201/eid1411.070467
Van De Sande-Bruinsma, Nienke ; Grundmann, Hajo ; Verloo, Didier ; Tiemersma, Edine ; Monen, Jos ; Goossens, Herman ; Ferech, Matus ; Mittermayer, H. ; Metz, S. ; Koller, W. ; Hendrickx, E. ; Markova, B. ; Tambic-Andrasevic, A. ; Francetic, Igor ; Kalenic, S. ; Bagatzouni, D. ; Dvorak, P. ; Urbaskova, P. ; Monnet, D. ; Anker Nielsen, A. ; Naaber, P. ; Huovinen, P. ; Paakkari, P. ; Lyytikainen, O. ; Nissinen, A. ; Maugendre, P. ; Guillemot, D. ; Coignard, B. ; Jarlier, V. ; Kern, W. ; Schroeder, H. ; Witte, W. ; Heckenbach, K. ; Giamarellou, H. ; Antoniadou, A. ; Tsakris, A. ; Vatopoulos, A. ; Ternák, G. ; Füzi, M. ; Kristinsson, K. ; Smyth, E. ; Cunney, R. ; Igoe, D. ; Murphy, O. ; Raz, R. ; Cornaglia, G. ; Pantosti, A. ; D'Ancona, P. ; Berzina, S. ; Balode, A. ; Valenteliene, R. ; Miciulevicience, J. ; Hemmer, R. ; Bruch, M. ; Borg, M. ; Zarb, P. ; Janknegt, R. ; Filius, M. ; De Neeling, H. ; Tiemermsa, E. ; Degener, J. ; Salvesen Blix, H. ; Hoiby, A. ; Simonsen, G. ; Hryniewicz, W. ; Grzesiowski, P. ; Caldeira, L. ; Canica, M. ; Codita, I. ; Foltan, V. ; Tesar, T. ; Langsadl, L. ; Cizman, M. ; Mueller-Premru, M. ; Kolman, J. ; Campos, J. ; Baquero, F. ; Cars, O. ; Skoog, G. ; Liljequist, B. ; Kahlmeter, G. ; Unal, S. ; Gür, D. ; Davey, P. ; Johnson, A. ; Hill, R. ; Hughes, H. ; Coyne, M. / Antimicrobial drug use and resistance in Europe. In: Emerging Infectious Diseases. 2008 ; Vol. 14, No. 11. pp. 1722-1730.
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AU - Van De Sande-Bruinsma, Nienke

AU - Grundmann, Hajo

AU - Verloo, Didier

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AU - Monen, Jos

AU - Goossens, Herman

AU - Ferech, Matus

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AU - Hendrickx, E.

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AU - Cars, O.

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