Antimicrobial activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines

N. Motohashi, H. Sakagami, T. Kurihara, L. Ferenczy, K. Csuri, J. Molnár

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The abilities of 14 phenothiazines, 8 benzo(a)phenothiazines and 12 benz[c]acridines to induce an antibacterial effect against Escherichia coli K12 were compared. Several phenothiazines, which showed antiplasmid activity, displayed the most potent antibacterial activity. All benz[c]acridine derivatives were moderately antibacterial, whereas benzo[a]phenothiazines were inactive: The active phenothiazine derivatives had more potent inhibitory activity against fungi, including phytopathogen filamentous, human pathogen filamentous fungi and yeasts, than against gram-positive and -negative bacteria. Taken together with previously reported data, the induction mechanism of antimicrobial and antiplasmid activity by these compounds seems to be different from that of antitumor, differentiation-inducing and carcinogenic activity.

Original languageEnglish
Pages (from-to)1207-1210
Number of pages4
JournalAnticancer Research
Volume12
Issue number4
Publication statusPublished - 1992

Fingerprint

Phenothiazines
Fungi
Escherichia coli K12
Gram-Positive Bacteria
Gram-Negative Bacteria
Yeasts
benzophenothiazine
benz(c)acridine
phenothiazine

Keywords

  • Antibacterial
  • Antifungal activity
  • Benz[c]acridines,
  • Benzo[a]phenothiazines
  • Phenothiazines

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Antimicrobial activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines. / Motohashi, N.; Sakagami, H.; Kurihara, T.; Ferenczy, L.; Csuri, K.; Molnár, J.

In: Anticancer Research, Vol. 12, No. 4, 1992, p. 1207-1210.

Research output: Contribution to journalArticle

Motohashi, N, Sakagami, H, Kurihara, T, Ferenczy, L, Csuri, K & Molnár, J 1992, 'Antimicrobial activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines', Anticancer Research, vol. 12, no. 4, pp. 1207-1210.
Motohashi, N. ; Sakagami, H. ; Kurihara, T. ; Ferenczy, L. ; Csuri, K. ; Molnár, J. / Antimicrobial activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines. In: Anticancer Research. 1992 ; Vol. 12, No. 4. pp. 1207-1210.
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AU - Csuri, K.

AU - Molnár, J.

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