Antiinflammatory effect of BPC 157 on experimental periodontitis in rats.

B. Keremi, Zs. Lohinai, P. Komora, S. Duhaj, K. Borsi, G. Jobbagy-Ovari, K. Kallo, A. Székely, A. Fazekas, C. Dobo-Nagy, P. Sikiric, G. Varga

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The pentadecapeptide BPC 157 has been shown to have anti-inflammatory and wound healing effects on multiple target tissues and organs. The purpose of the present study was to investigate the effect of BPC 157 on inflammation and bone resorption in experimental periodontitis in rats. First the acute effect of BPC was tested on gingival blood flow by laser doppler flowmetry. Then periodontitis was produced by a silk ligature placed around the lower left first molar. Rats were treated with BPC 157 (once daily for 12 days) or vehicle. At day 13, the gingivomucosal tissues encircling the molars were removed on both sides. Inflammation was assessed by Evans blue plasma extravasation technique and by histology. Alveolar bone loss was analyzed by microCT. BPC 157 had no effect on gingivomucosal blood flow. Twelve day ligature caused a significantly increased Evans blue extravasation in the gingivomucosal tissue, histological signs of inflammation, and alveolar bone destruction. BPC 157 treatment significantly reduced both plasma extravasation, histological alterations and alveolar bone resorption. In conclusion, systemic application of BPC 157 does not alter blood circulation in healthy gingiva. Chronic application of the peptide has potent antiinflammatory effects on periodontal tissues in ligature induced periodontitis in rats. Taken together, this proof of concept study suggests that BPC 157 may represent a new peptide candidate in the treatment of periodontal disease.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalJournal of Physiology and Pharmacology
Volume60 Suppl 7
Publication statusPublished - Dec 2009

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Periodontitis
Anti-Inflammatory Agents
Alveolar Bone Loss
Ligation
Evans Blue
Bone Resorption
Inflammation
Osteitis
X-Ray Microtomography
Peptides
Laser-Doppler Flowmetry
Silk
Blood Circulation
Gingiva
Periodontal Diseases
BPC 157
Wound Healing
Histology
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Keremi, B., Lohinai, Z., Komora, P., Duhaj, S., Borsi, K., Jobbagy-Ovari, G., ... Varga, G. (2009). Antiinflammatory effect of BPC 157 on experimental periodontitis in rats. Journal of Physiology and Pharmacology, 60 Suppl 7, 115-122.

Antiinflammatory effect of BPC 157 on experimental periodontitis in rats. / Keremi, B.; Lohinai, Zs.; Komora, P.; Duhaj, S.; Borsi, K.; Jobbagy-Ovari, G.; Kallo, K.; Székely, A.; Fazekas, A.; Dobo-Nagy, C.; Sikiric, P.; Varga, G.

In: Journal of Physiology and Pharmacology, Vol. 60 Suppl 7, 12.2009, p. 115-122.

Research output: Contribution to journalArticle

Keremi, B, Lohinai, Z, Komora, P, Duhaj, S, Borsi, K, Jobbagy-Ovari, G, Kallo, K, Székely, A, Fazekas, A, Dobo-Nagy, C, Sikiric, P & Varga, G 2009, 'Antiinflammatory effect of BPC 157 on experimental periodontitis in rats.', Journal of Physiology and Pharmacology, vol. 60 Suppl 7, pp. 115-122.
Keremi B, Lohinai Z, Komora P, Duhaj S, Borsi K, Jobbagy-Ovari G et al. Antiinflammatory effect of BPC 157 on experimental periodontitis in rats. Journal of Physiology and Pharmacology. 2009 Dec;60 Suppl 7:115-122.
Keremi, B. ; Lohinai, Zs. ; Komora, P. ; Duhaj, S. ; Borsi, K. ; Jobbagy-Ovari, G. ; Kallo, K. ; Székely, A. ; Fazekas, A. ; Dobo-Nagy, C. ; Sikiric, P. ; Varga, G. / Antiinflammatory effect of BPC 157 on experimental periodontitis in rats. In: Journal of Physiology and Pharmacology. 2009 ; Vol. 60 Suppl 7. pp. 115-122.
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