Antihypertensive effect of bopindolol: A multi-centre study

E. Torok, I. Szam, G. Buday, G. Kerkovits, C. Farsang, B. Hajtman

Research output: Contribution to journalArticle

Abstract

The objective of the study was to investigate the efficacy of different dose levels of bopindolol monotherapy in hypertension. This potent nonselective beta-adrenergic receptor blocker has intrinsic sympathomimetic activity and long duration of action. Forty-four patients with essential hypertension of mild (n=40) or moderate (n=4) severity (90<DBP≤115 mmHg at the end of the placebo period) entered and completed the single-blind, placebo-controlled trial. The study lasted 14 weeks: 2 weeks on placebo, and 12 weeks on active treatment during which the initial dose of bipindolol, 1 mg daily, was augmented up to 1.5 mg, then to 2 mg at four-week intervals until BP normalized or a maximum dose of 2 mg/day bopindolol was reached. The bopindolol was administered once a day in the morning. Patients were seen every other week in the morning before drug taking, when BP and heart rate, supine and standing, a twelve lead ECG and side-effects were recorded. Compared with placebo, supine BP was significantly reduced by bopindolol: from 169±2/103±1 mmHg to 148±3/92±1, 144±3/90±1 and 136±2/85±0.6 mmHg at the end of 4, 8 and 12 weeks of treatments, respectively (P<0.01 for each). BP changes during standing were similar. Bopindolol lowered the supine heart rate from 84±2 to 75±1, 74±1, 72±1 beats/min (P<0.01). BP was normalized in all but two patients with a mean dose of 1.5 mg bopindolol daily. No side-effects of clinical importance were noted.

Original languageEnglish
Pages (from-to)458-460
Number of pages3
JournalJournal of Human Hypertension
Volume4
Issue number4
Publication statusPublished - Jan 1 1990

ASJC Scopus subject areas

  • Internal Medicine

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    Torok, E., Szam, I., Buday, G., Kerkovits, G., Farsang, C., & Hajtman, B. (1990). Antihypertensive effect of bopindolol: A multi-centre study. Journal of Human Hypertension, 4(4), 458-460.