Antigranulocyte antibodies in patients with systemic lupus erythematosus (SLE).

A. Sipos, T. Seres, G. Szegedi

Research output: Contribution to journalArticle

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Abstract

Antigranulocyte antibodies were studied in patients with systemic lupus erythematosus. The frequency and type of the antibodies were identified with ELISA (Enzyme-Linked Immunosorbent Assay) and MGCT (microgranulocytotoxicity test). To check antibody specificity, a LCT (lymphocytotoxicity test) was used parallel with the above technique. The ELISA proved to be suitable for determining antigranulocyte antibodies. There was a correlation between the serum level of IgG-type antigranulocyte antibodies and granulocytopenia, but the IgM-type antigranulocyte antibodies failed to show a similar correlation. A good parallelism was found between MGCT--a test to be used to determine IgM-type antibodies--and the IgM-type antigranulocyte antibodies determined by ELISA. Of 25 SLE sera, 13 were found positive for antigranulocyte antibodies. LCT was used to examine the presence of HLA antibodies in these sera and 39% of the sera positive for antigranulocyte antibodies appeared to be granulocyte-specific while 61% reacted in the LCT, too.

Original languageEnglish
Pages (from-to)299-310
Number of pages12
JournalActa Medica Hungarica
Volume44
Issue number4
Publication statusPublished - 1987

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Systemic Lupus Erythematosus
Antibodies
Immunoglobulin M
Enzyme-Linked Immunosorbent Assay
Serum
Agranulocytosis
Antibody Specificity
Granulocytes
Immunoglobulin G

ASJC Scopus subject areas

  • Medicine(all)

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Antigranulocyte antibodies in patients with systemic lupus erythematosus (SLE). / Sipos, A.; Seres, T.; Szegedi, G.

In: Acta Medica Hungarica, Vol. 44, No. 4, 1987, p. 299-310.

Research output: Contribution to journalArticle

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