Antigliadin and antireticulin antibodies in children with dermatitis herpetiformis

Eeva Vainio, Istvan Kosnai, Olavi Hällström, S. Kárpáti, Markku MäKi, Timo Reunala

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The serum samples of 27 children with dermatitis herpetiformis (DH) were examined for the presence of antigliadin (AGA) and antireticulin (ARA) antibodies. AGA were determined with an enzyme-linked immunosorbent assay (ELISA) and ARA with an immunofluorescence method. Increased IgA or IgG class AGA levels were found in four of ten children on a normal diet, in two of 25 on a gluten-free diet (GFD), and in two of four children on gluten challenge. The corresponding figures for ARA were nine of ten, two of 25, and four of four, respectively. All nine patients with ARA on a normal diet had either subtotal or partial villous atrophy, whereas the patient negative for ARA had a normal jejunal mucosa. ARA were mostly of IgA class, and after gluten with-drawal, increased levels fell to normal range. Four children were challenged with gluten, and they all developed subtotal villous atrophy and demonstrated IgA class ARA. These results suggest that in childhood DH. ARA is a more sensitive indicator of gluten-sensitive enteropathy than AGA, but both antibody determinations can be used in monitoring adherence to GFD treatment.

Original languageEnglish
Pages (from-to)735-739
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume5
Issue number5
Publication statusPublished - 1986

Fingerprint

Dermatitis Herpetiformis
dermatitis
Glutens
gluten
Immunoglobulin A
gluten-free diet
Gluten-Free Diet
antibodies
Antibodies
atrophy
Atrophy
Diet
celiac disease
Celiac Disease
childhood
diet
fluorescent antibody technique
mucosa
Fluorescent Antibody Technique
Reference Values

Keywords

  • Celiac disease
  • Dermatitis herpetiformis
  • Gliadin and reticulin antibodies
  • Gluten-free diet

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health
  • Food Science
  • Medicine (miscellaneous)
  • Histology

Cite this

Antigliadin and antireticulin antibodies in children with dermatitis herpetiformis. / Vainio, Eeva; Kosnai, Istvan; Hällström, Olavi; Kárpáti, S.; MäKi, Markku; Reunala, Timo.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 5, No. 5, 1986, p. 735-739.

Research output: Contribution to journalArticle

Vainio, E, Kosnai, I, Hällström, O, Kárpáti, S, MäKi, M & Reunala, T 1986, 'Antigliadin and antireticulin antibodies in children with dermatitis herpetiformis', Journal of Pediatric Gastroenterology and Nutrition, vol. 5, no. 5, pp. 735-739.
Vainio, Eeva ; Kosnai, Istvan ; Hällström, Olavi ; Kárpáti, S. ; MäKi, Markku ; Reunala, Timo. / Antigliadin and antireticulin antibodies in children with dermatitis herpetiformis. In: Journal of Pediatric Gastroenterology and Nutrition. 1986 ; Vol. 5, No. 5. pp. 735-739.
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