Antigen-specific lymphocyte clone elimination and reappearance in guinea pigs using125i-labelled horse serum albumin

J. Pongrácz, Éva Ölveti, B. Csaba

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

T cells in the blood and spleen of guinea pigs fixed significantly higher quantities of radiolabelled antigen on day 4 following injection than did B cells or macrophages. Fixed radioactivity produced continuous radiation damage on the cells involved and the antigen-specific lymphocyte clone disappeared. This was shown by the absence of antibody production in the sera determined by passive haemagglutination. The reappearance of the specific lymphocyte clone required more than 20 days.

Original languageEnglish
Pages (from-to)260-262
Number of pages3
JournalInternational Archives of Allergy and Immunology
Volume87
Issue number3
DOIs
Publication statusPublished - 1988

Fingerprint

Serum Albumin
Horses
Guinea Pigs
Clone Cells
Lymphocytes
Antigens
Hemagglutination
Radioactivity
Antibody Formation
B-Lymphocytes
Spleen
Macrophages
Radiation
T-Lymphocytes
Injections
Serum

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Antigen-specific lymphocyte clone elimination and reappearance in guinea pigs using125i-labelled horse serum albumin. / Pongrácz, J.; Ölveti, Éva; Csaba, B.

In: International Archives of Allergy and Immunology, Vol. 87, No. 3, 1988, p. 260-262.

Research output: Contribution to journalArticle

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