Antigen-presenting cells under the influence of alcohol

Audrey H. Lau, Gyongyi Szabo, Angus W. Thomson

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

The negative influence of alcohol (ethanol) and its metabolites on innate and adaptive immunity is well-recognized. Much attention has recently been focused on the impact of acute and chronic alcohol exposure on antigen-presenting cells (APC). In particular, insights have been gained into how the properties of human blood monocytes and rodent macrophages are influenced by alcohol in vitro and in vivo. Here, we review the impact of alcohol on various aspects of APC function and the underlying mechanisms, including its effects on intracellular signaling events. We also discuss new information regarding the influence of alcohol on various APC populations in the liver, a primary site of alcohol metabolism.

Original languageEnglish
Pages (from-to)13-22
Number of pages10
JournalTrends in Immunology
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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