Antigen microarrays: descriptive chemistry or functional immunomics?

József Prechl, Krisztián Papp, Anna Erdei

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Advances in protein microarray technology allow the generation of high content, reliable information about complex, multilevel protein interaction networks. Yet antigen arrays are used mostly only as devices for parallel immune assays describing multitudes of individual binding events. We propose here that the huge amount of immunological information hidden in the plasma of an individual could be better revealed by combining the characterization of antibody binding to target epitopes with improved estimation of effector functions triggered by these binding events. Furthermore, we could generate functional immune profiles characterizing general immune responsiveness of the individual by designing arrays incorporating epitope collections from diverse subsets of antibody targets.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalTrends in Immunology
Volume31
Issue number4
DOIs
Publication statusPublished - Apr 1 2010

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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