Antifungal Effect of Essential Oils against Fusarium Keratitis Isolates

Mónika Homa, Ildikó Pálma Fekete, Andrea Böszörményi, Yendrembam Randhir Babu Singh, Kanesan Panneer Selvam, Coimbatore Subramanian Shobana, Palanisamy Manikandan, László Kredics, Csaba Vágvölgyi, László Galgóczy

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13 Citations (Scopus)


The present study was carried out to investigate the antifungal effects of Cinnamomum zeylanicum, Citrus limon, Juniperus communis, Eucalyptus citriodora, Gaultheria procumbens, Melaleuca alternifolia, Origanum majorana, Salvia sclarea, and Thymus vulgaris essential oils against Fusarium species, the most common etiologic agents of filamentous fungal keratitis in South India. C. zeylanicum essential oil showed strong anti-Fusarium activity, whereas all the other tested essential oils proved to be less effective. The main component of C. zeylanicum essential oil, trans-cinnamaldehyde, was also tested and showed a similar effect as the oil. The in vitro interaction between trans-cinnamaldehyde and natamycin, the first-line therapeutic agent of Fusarium keratitis, was also investigated; an enhanced fungal growth inhibition was observed when these agents were applied in combination. Light and fluorescent microscopic observations revealed that C. zeylanicum essential oil/trans-cinnamaldehyde reduces the cellular metabolism and inhibits the conidia germination. Furthermore, necrotic events were significantly more frequent in the presence of these two compounds. According to our results, C. zeylanicum essential oil/trans-cinnamaldehyde provides a promising basis to develop a novel strategy for the treatment of Fusarium keratitis.

Original languageEnglish
Pages (from-to)1277-1284
Number of pages8
JournalPlanta Medica
Issue number14
Publication statusPublished - Jul 30 2015


  • Cinnamomum zeylanicum
  • Fusarium keratitis
  • Lauraceae
  • antifungal effect
  • essential oils
  • trans-cinnamaldehyde

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Homa, M., Fekete, I. P., Böszörményi, A., Singh, Y. R. B., Selvam, K. P., Shobana, C. S., Manikandan, P., Kredics, L., Vágvölgyi, C., & Galgóczy, L. (2015). Antifungal Effect of Essential Oils against Fusarium Keratitis Isolates. Planta Medica, 81(14), 1277-1284.