Antiestrogens, antiandrogens.

J. Borvendég, I. Hermann, O. Csuka

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The aim of the study was to find new antiestrogenic and antiandrogenic structures. Out of the triphenyl-alkene derivatives Panomifene (EGIS-5660) proved to be the most active antiestrogenic compound which binds to specific estrogen receptors and exhibits inhibitory effects on experimental mammary tumors both in vitro and in vivo. The investigated antiandrogenic compounds were indol and imidazole derivatives. One of these compounds a di-imidazolil derivative, GYK1-24479 inhibited the in vitro androgen (testosterone and androstenedione) biosynthesis both in vitro and in vivo in concentration/dose dependent manner, and in these respects proved to be more active than the referent ketoconazole.

Original languageEnglish
Pages (from-to)405-406
Number of pages2
JournalActa Physiologica Hungarica
Volume84
Issue number4
Publication statusPublished - 1996

Fingerprint

Androgen Antagonists
Estrogen Receptor Modulators
Ketoconazole
Androstenedione
Alkenes
Estrogen Receptors
Androgens
Testosterone
Breast Neoplasms
In Vitro Techniques

ASJC Scopus subject areas

  • Physiology

Cite this

Borvendég, J., Hermann, I., & Csuka, O. (1996). Antiestrogens, antiandrogens. Acta Physiologica Hungarica, 84(4), 405-406.

Antiestrogens, antiandrogens. / Borvendég, J.; Hermann, I.; Csuka, O.

In: Acta Physiologica Hungarica, Vol. 84, No. 4, 1996, p. 405-406.

Research output: Contribution to journalArticle

Borvendég, J, Hermann, I & Csuka, O 1996, 'Antiestrogens, antiandrogens.', Acta Physiologica Hungarica, vol. 84, no. 4, pp. 405-406.
Borvendég J, Hermann I, Csuka O. Antiestrogens, antiandrogens. Acta Physiologica Hungarica. 1996;84(4):405-406.
Borvendég, J. ; Hermann, I. ; Csuka, O. / Antiestrogens, antiandrogens. In: Acta Physiologica Hungarica. 1996 ; Vol. 84, No. 4. pp. 405-406.
@article{50833edc6c2d4f8f95483cf80f976102,
title = "Antiestrogens, antiandrogens.",
abstract = "The aim of the study was to find new antiestrogenic and antiandrogenic structures. Out of the triphenyl-alkene derivatives Panomifene (EGIS-5660) proved to be the most active antiestrogenic compound which binds to specific estrogen receptors and exhibits inhibitory effects on experimental mammary tumors both in vitro and in vivo. The investigated antiandrogenic compounds were indol and imidazole derivatives. One of these compounds a di-imidazolil derivative, GYK1-24479 inhibited the in vitro androgen (testosterone and androstenedione) biosynthesis both in vitro and in vivo in concentration/dose dependent manner, and in these respects proved to be more active than the referent ketoconazole.",
author = "J. Borvend{\'e}g and I. Hermann and O. Csuka",
year = "1996",
language = "English",
volume = "84",
pages = "405--406",
journal = "Physiology International",
issn = "2498-602X",
publisher = "Akademiai Kiado",
number = "4",

}

TY - JOUR

T1 - Antiestrogens, antiandrogens.

AU - Borvendég, J.

AU - Hermann, I.

AU - Csuka, O.

PY - 1996

Y1 - 1996

N2 - The aim of the study was to find new antiestrogenic and antiandrogenic structures. Out of the triphenyl-alkene derivatives Panomifene (EGIS-5660) proved to be the most active antiestrogenic compound which binds to specific estrogen receptors and exhibits inhibitory effects on experimental mammary tumors both in vitro and in vivo. The investigated antiandrogenic compounds were indol and imidazole derivatives. One of these compounds a di-imidazolil derivative, GYK1-24479 inhibited the in vitro androgen (testosterone and androstenedione) biosynthesis both in vitro and in vivo in concentration/dose dependent manner, and in these respects proved to be more active than the referent ketoconazole.

AB - The aim of the study was to find new antiestrogenic and antiandrogenic structures. Out of the triphenyl-alkene derivatives Panomifene (EGIS-5660) proved to be the most active antiestrogenic compound which binds to specific estrogen receptors and exhibits inhibitory effects on experimental mammary tumors both in vitro and in vivo. The investigated antiandrogenic compounds were indol and imidazole derivatives. One of these compounds a di-imidazolil derivative, GYK1-24479 inhibited the in vitro androgen (testosterone and androstenedione) biosynthesis both in vitro and in vivo in concentration/dose dependent manner, and in these respects proved to be more active than the referent ketoconazole.

UR - http://www.scopus.com/inward/record.url?scp=0030310241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030310241&partnerID=8YFLogxK

M3 - Article

VL - 84

SP - 405

EP - 406

JO - Physiology International

JF - Physiology International

SN - 2498-602X

IS - 4

ER -