Antidromic vasodilatation in the striated muscle and its sensitivity to resiniferatoxin in the rat

Research output: Contribution to journalArticle

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Abstract

Antidromic stimulation at the L4-L5 dorsal roots elicited a blood flow increase in ipsilateral muscles of lower extremities in rats measured by laser-Doppler flowmetry. Stimulation with 0.5 Hz; 20 V; 0.5 ms; 50 impulses was much less effective in muscle (18.9 ± 6.4 area under the curve (%); mean ± S.E.) than in the glabrous skin (80.5 ± 8.25; P <0.001). No significant difference was seen at 10 Hz (51.6 ± 10.6 muscle; 60.6 ± 17.3 skin). In the muscle the latency period of the response was long (37.4 ± 3.1 s; mean ± S.E.) at 0.5 Hz stimulation and was much shorter (8.8 ± 0.8 s) at the higher frequency of 10 Hz, unlike in the skin where latency values at both frequencies were similar (9.7 ± 0.8 s and 8.9 ± 0.9 s, respectively). Antidromic vasodilatation in the muscle and the skin was abolished by resiniferatoxin (RTX) in an i.v. dose of 1.0 μg/kg. These results provide a direct evidence for the existence of antidromic vasodilatation in striated muscle and suggest a mediating role for capsaicin/RTX sensitive afferents.

Original languageEnglish
Pages (from-to)267-270
Number of pages4
JournalNeuroscience Letters
Volume182
Issue number2
DOIs
Publication statusPublished - Dec 5 1994

Fingerprint

Striated Muscle
Vasodilation
Muscles
Skin
Laser-Doppler Flowmetry
Spinal Nerve Roots
Capsaicin
Area Under Curve
Lower Extremity
resiniferatoxin

Keywords

  • Antidromic vasodilatation
  • Blood flow
  • Dorsal root
  • Laser-Doppler
  • Rat
  • Resiniferatoxin
  • Striated muscle

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Antidromic vasodilatation in the striated muscle and its sensitivity to resiniferatoxin in the rat. / Pórszász, R.; Szolcsányi, J.

In: Neuroscience Letters, Vol. 182, No. 2, 05.12.1994, p. 267-270.

Research output: Contribution to journalArticle

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