Antidepressant-resistant depression and antidepressant-associated suicidal behaviour

The role of underlying bipolarity

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30 Citations (Scopus)

Abstract

The complex relationship between the use of antidepressants and suicidal behaviour is one of the hottest topics of our contemporary psychiatry. Based on the literature, this paper summarizes the author's view on antidepressant- resistant depression and antidepressant-associated suicidal behaviour. Antidepressant-resistance, antidepressant-induced worsening of depression, antidepressant-associated (hypo)manic switches, mixed depressive episode, and antidepressant-associated suicidality among depressed patients are relatively most frequent in bipolar/bipolar spectrum depression and in children and adolescents. As early age at onset of major depressive episode and mixed depression are powerful clinical markers of bipolarity and the manic component of bipolar disorder (and possible its biological background) shows a declining tendency with age antidepressant-resistance/worsening, antidepressant-induced (hypo)manic switches and "suicide-inducing" potential of antidepressants seem to be related to the underlying bipolarity.

Original languageEnglish
Article number906462
JournalDepression Research and Treatment
Volume2011
DOIs
Publication statusPublished - 2011

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Antidepressive Agents
Depression
Bipolar Disorder
Age of Onset
Suicide
Psychiatry
Biomarkers

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

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