Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion

Jan Rybniker, Jeffrey M. Chen, Claudia Sala, Ruben C. Hartkoorn, Anthony Vocat, Andrej Benjak, Stefanie Boy-Röttger, Ming Zhang, Rita Székely, Zoltán Greff, László Orfi, István Szabadkai, János Pató, György Kéri, Stewart T. Cole

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Mtb EsxA secretion can be targeted in high-throughput screensSmall molecules abrogate EsxA secretion and reduce intracellular bacterial loadsInhibitor BTP15 targets kinase MprB that indirectly regulates ESX-1BBH7 affects Mtb ion homeostasis, revealing a role for zinc stress in ESX-1 regulation

Original languageEnglish
Pages (from-to)538-548
Number of pages11
JournalCell Host and Microbe
Volume16
Issue number4
DOIs
Publication statusPublished - Oct 8 2014

    Fingerprint

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

Cite this

Rybniker, J., Chen, J. M., Sala, C., Hartkoorn, R. C., Vocat, A., Benjak, A., Boy-Röttger, S., Zhang, M., Székely, R., Greff, Z., Orfi, L., Szabadkai, I., Pató, J., Kéri, G., & Cole, S. T. (2014). Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion. Cell Host and Microbe, 16(4), 538-548. https://doi.org/10.1016/j.chom.2014.09.008