Anticonvulsive effects of galanin administered into the central nervous system upon the picrotoxin-kindled seizure syndrome in rats

Andrey M. Mazarati, Eva Halászi, Gyula Telegdy

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Galanin (2000, 1000 ng) administered into the lateral brain ventricle decreased the severity of picrotoxin-kindled convulsion in rats. The bilateral injection (200, 100 and 50 ng) of galanin into the hippocampus also evoked an anticonvulsive effect. When administered into the caudate nuclei or substantia nigra reticulata, galanin exerted anticonvulsive action only in a high dose (200 ng), whereas in the nucleus accumbens it did so in a low dose (50 ng). When administered into the ventral tegmental area in a dose of 50, 100 or 200 ng galanin failed to reduce the manifestations of picrotoxin-kindled seizures.

Original languageEnglish
Pages (from-to)164-166
Number of pages3
JournalBrain research
Volume589
Issue number1
DOIs
Publication statusPublished - Aug 28 1992

Keywords

  • Anticonvulsive effect
  • Brain structure
  • Galanin
  • Picrotoxin kindling

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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