Anticonvulsive effect of urethane on aminopyridine-induced epileptiform activity

Gabor Heltovics, Bernadett Boda, M. Szente

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

THE effects of urethane anaesthesia on the development and spread of ictal-like epileptiform activity induced by 3-aminopyridine, was investigated on the somatosensory cortex of rats. Under urethane anaesthesia in most animals only one abortive ictal period appeared with dose-dependent latency. Urethane completely abolished high frequency afterdischarges (5-10 Hz) and prevented the development of recurrent seizures in both primary and mirror foci. Urethane also eliminated ongoing epileptiform activity induced previously by 3-aminopyridine under nembutal anaesthesia. The antiepileptic effects of urethane on ictal-like activity may be the consequence of a presynaptic action through reduction of glutamate-mediated excitation together with a depressant effect on responsiveness of cortical neurones. The afterdischarges of high frequency could be essential to development and stabilization of repetitive tonic events in the neocortex.

Original languageEnglish
Pages (from-to)577-580
Number of pages4
JournalNeuroReport
Volume6
Issue number3
Publication statusPublished - 1995

Fingerprint

Aminopyridines
Urethane
Anesthesia
Stroke
Somatosensory Cortex
Neocortex
Pentobarbital
Anticonvulsants
Glutamic Acid
Seizures
Neurons

Keywords

  • Aminopyridine
  • Anticonvulsive
  • Neocortical ictal activity
  • Secondary epileptogenesis
  • Urethane

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Anticonvulsive effect of urethane on aminopyridine-induced epileptiform activity. / Heltovics, Gabor; Boda, Bernadett; Szente, M.

In: NeuroReport, Vol. 6, No. 3, 1995, p. 577-580.

Research output: Contribution to journalArticle

Heltovics, Gabor ; Boda, Bernadett ; Szente, M. / Anticonvulsive effect of urethane on aminopyridine-induced epileptiform activity. In: NeuroReport. 1995 ; Vol. 6, No. 3. pp. 577-580.
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