Antibody-Mediated Rejection in a Multiple Lung Transplant Patient: A Case Report

P. Radeczky, K. Ghimessy, A. Farkas, K. Csende, L. Mészáros, K. Török, L. Fazekas, L. Agócs, Kocsis, T. Bartók, T. Dancs, K. K. Tóth, N. Schönauer, L. Bogyó, A. Bohács, I. Madurka, J. Elek, B. Döme, F. Rényi-Vámos, G. LangB. Gieszer

Research output: Contribution to journalArticle

Abstract

Lung transplant is an effective way to treat many end-stage lung diseases. However, one of the main barriers of allograft organ transplant is still the immunologic rejection of transplanted tissue, which is a response of the HLA molecules. Rejection is a complex process involving both T-cell–mediated delayed-type hypersensitivity reactions and antibody-mediated hypersensitivity reactions to histocompatibility molecules on foreign grafts. We report the case of a 25-year-old female patient with cystic fibrosis who underwent 2 lung transplants because of her initial diagnosis and appearance of bronchiolitis obliterans syndrome after the first transplant. Only 13 months after the second transplant, despite the therapies applied, a new rejection occurred associated with high mean fluorescent intensity donor-specific antibody levels, which resulted later in the death of the patient. The present case draws attention to the importance of matching HLA molecules between donor and recipient in addition to immunosuppressive therapy.

Original languageEnglish
Pages (from-to)1296-1298
Number of pages3
JournalTransplantation Proceedings
Volume51
Issue number4
DOIs
Publication statusPublished - May 1 2019

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Transplants
Lung
Antibodies
Tissue Donors
Bronchiolitis Obliterans
Histocompatibility
Delayed Hypersensitivity
Immunosuppressive Agents
Cystic Fibrosis
Lung Diseases
Allografts
Hypersensitivity
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Radeczky, P., Ghimessy, K., Farkas, A., Csende, K., Mészáros, L., Török, K., ... Gieszer, B. (2019). Antibody-Mediated Rejection in a Multiple Lung Transplant Patient: A Case Report. Transplantation Proceedings, 51(4), 1296-1298. https://doi.org/10.1016/j.transproceed.2019.03.005

Antibody-Mediated Rejection in a Multiple Lung Transplant Patient : A Case Report. / Radeczky, P.; Ghimessy, K.; Farkas, A.; Csende, K.; Mészáros, L.; Török, K.; Fazekas, L.; Agócs, L.; Kocsis; Bartók, T.; Dancs, T.; Tóth, K. K.; Schönauer, N.; Bogyó, L.; Bohács, A.; Madurka, I.; Elek, J.; Döme, B.; Rényi-Vámos, F.; Lang, G.; Gieszer, B.

In: Transplantation Proceedings, Vol. 51, No. 4, 01.05.2019, p. 1296-1298.

Research output: Contribution to journalArticle

Radeczky, P, Ghimessy, K, Farkas, A, Csende, K, Mészáros, L, Török, K, Fazekas, L, Agócs, L, Kocsis, Bartók, T, Dancs, T, Tóth, KK, Schönauer, N, Bogyó, L, Bohács, A, Madurka, I, Elek, J, Döme, B, Rényi-Vámos, F, Lang, G & Gieszer, B 2019, 'Antibody-Mediated Rejection in a Multiple Lung Transplant Patient: A Case Report', Transplantation Proceedings, vol. 51, no. 4, pp. 1296-1298. https://doi.org/10.1016/j.transproceed.2019.03.005
Radeczky P, Ghimessy K, Farkas A, Csende K, Mészáros L, Török K et al. Antibody-Mediated Rejection in a Multiple Lung Transplant Patient: A Case Report. Transplantation Proceedings. 2019 May 1;51(4):1296-1298. https://doi.org/10.1016/j.transproceed.2019.03.005
Radeczky, P. ; Ghimessy, K. ; Farkas, A. ; Csende, K. ; Mészáros, L. ; Török, K. ; Fazekas, L. ; Agócs, L. ; Kocsis ; Bartók, T. ; Dancs, T. ; Tóth, K. K. ; Schönauer, N. ; Bogyó, L. ; Bohács, A. ; Madurka, I. ; Elek, J. ; Döme, B. ; Rényi-Vámos, F. ; Lang, G. ; Gieszer, B. / Antibody-Mediated Rejection in a Multiple Lung Transplant Patient : A Case Report. In: Transplantation Proceedings. 2019 ; Vol. 51, No. 4. pp. 1296-1298.
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