Antibody-dependent enhancement of HIV-1 infection in human term syncytiotrophoblast cells cultured in vitro

F. D. Toth, P. Mosborg-Petersen, J. Kiss, G. Aboagye-Mathiesen, M. Zdravkovic, H. Hager, J. Aranyosi, L. Lampe, P. Ebbesen

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Abstract

We examined if Fc receptor-mediated antibody-dependent enhancement (FcR- ADE) or complement-mediated antibody-dependent enhancement (C'-ADE) of virus infection can contribute to increasing replication of HIV-1 in human syncytiotrophoblast (ST) cells. Here we report that both FcR-ADE and C'-ADE may result in enhanced virus release from HIV-1-infected ST cells. We show that FcR-ADE of HIV-1 infection in ST cells is mediated by FcRIII and other FcR(s) belonging to undetermined Fc classes and does not require CD4 receptors, whereas C'-ADE uses both CD4 and CR2-like receptors. FcR-ADE seems to be more efficient in enhancing HIV-1 replication than C'-ADE. While FcR- ADE leads to increased internalization of HIV-1, C'-ADE does not result in enhanced endocytosis of the virus. In addition, antibodies mediating FcR-ADE are reactive with the gp120 viral envelope antigen, whereas antibodies involved in C'-ADE react with the viral transmembrane glycoprotein gp41. Data suggest that both FcR-ADE and C'-ADE may contribute to the spread of HIV-1 from mother to the fetus.

Original languageEnglish
Pages (from-to)389-394
Number of pages6
JournalClinical and Experimental Immunology
Volume96
Issue number3
Publication statusPublished - Jan 1 1994

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Keywords

  • Fc receptors
  • HIV
  • complement receptors
  • enhancement
  • syncytiotrophoblast

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Toth, F. D., Mosborg-Petersen, P., Kiss, J., Aboagye-Mathiesen, G., Zdravkovic, M., Hager, H., Aranyosi, J., Lampe, L., & Ebbesen, P. (1994). Antibody-dependent enhancement of HIV-1 infection in human term syncytiotrophoblast cells cultured in vitro. Clinical and Experimental Immunology, 96(3), 389-394.