Antibody-dependent enhancement of HIV-1 infection in human term syncytiotrophoblast cells cultured in vitro

F. Tóth, P. Mosborg-Petersen, J. Kiss, G. Aboagye-Mathiesen, M. Zdravkovic, H. Hager, J. Aranyosi, L. Lampe, P. Ebbesen

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Abstract

We examined if Fc receptor-mediated antibody-dependent enhancement (FcR- ADE) or complement-mediated antibody-dependent enhancement (C'-ADE) of virus infection can contribute to increasing replication of HIV-1 in human syncytiotrophoblast (ST) cells. Here we report that both FcR-ADE and C'-ADE may result in enhanced virus release from HIV-1-infected ST cells. We show that FcR-ADE of HIV-1 infection in ST cells is mediated by FcRIII and other FcR(s) belonging to undetermined Fc classes and does not require CD4 receptors, whereas C'-ADE uses both CD4 and CR2-like receptors. FcR-ADE seems to be more efficient in enhancing HIV-1 replication than C'-ADE. While FcR- ADE leads to increased internalization of HIV-1, C'-ADE does not result in enhanced endocytosis of the virus. In addition, antibodies mediating FcR-ADE are reactive with the gp120 viral envelope antigen, whereas antibodies involved in C'-ADE react with the viral transmembrane glycoprotein gp41. Data suggest that both FcR-ADE and C'-ADE may contribute to the spread of HIV-1 from mother to the fetus.

Original languageEnglish
Pages (from-to)389-394
Number of pages6
JournalClinical and Experimental Immunology
Volume96
Issue number3
Publication statusPublished - 1994

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Antibody-Dependent Enhancement
Trophoblasts
HIV Infections
HIV-1
Cultured Cells
Fc Receptors
Complement 3d Receptors
Virus Release
In Vitro Techniques
CD4 Antigens
Viral Antigens
Antibodies
Virus Diseases
Endocytosis
Glycoproteins
Fetus

Keywords

  • complement receptors
  • enhancement
  • Fc receptors
  • HIV
  • syncytiotrophoblast

ASJC Scopus subject areas

  • Immunology

Cite this

Tóth, F., Mosborg-Petersen, P., Kiss, J., Aboagye-Mathiesen, G., Zdravkovic, M., Hager, H., ... Ebbesen, P. (1994). Antibody-dependent enhancement of HIV-1 infection in human term syncytiotrophoblast cells cultured in vitro. Clinical and Experimental Immunology, 96(3), 389-394.

Antibody-dependent enhancement of HIV-1 infection in human term syncytiotrophoblast cells cultured in vitro. / Tóth, F.; Mosborg-Petersen, P.; Kiss, J.; Aboagye-Mathiesen, G.; Zdravkovic, M.; Hager, H.; Aranyosi, J.; Lampe, L.; Ebbesen, P.

In: Clinical and Experimental Immunology, Vol. 96, No. 3, 1994, p. 389-394.

Research output: Contribution to journalArticle

Tóth, F, Mosborg-Petersen, P, Kiss, J, Aboagye-Mathiesen, G, Zdravkovic, M, Hager, H, Aranyosi, J, Lampe, L & Ebbesen, P 1994, 'Antibody-dependent enhancement of HIV-1 infection in human term syncytiotrophoblast cells cultured in vitro', Clinical and Experimental Immunology, vol. 96, no. 3, pp. 389-394.
Tóth F, Mosborg-Petersen P, Kiss J, Aboagye-Mathiesen G, Zdravkovic M, Hager H et al. Antibody-dependent enhancement of HIV-1 infection in human term syncytiotrophoblast cells cultured in vitro. Clinical and Experimental Immunology. 1994;96(3):389-394.
Tóth, F. ; Mosborg-Petersen, P. ; Kiss, J. ; Aboagye-Mathiesen, G. ; Zdravkovic, M. ; Hager, H. ; Aranyosi, J. ; Lampe, L. ; Ebbesen, P. / Antibody-dependent enhancement of HIV-1 infection in human term syncytiotrophoblast cells cultured in vitro. In: Clinical and Experimental Immunology. 1994 ; Vol. 96, No. 3. pp. 389-394.
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