Antibody dependent and spontaneous lymphocyte mediated cytotoxicity in normal subjects, patients with SLE, and malignancies

I. Lang, M. Benczur, M. Varga, P. Gergely, G. Petrányi

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Abstract

Antibody dependent and spontaneous lymphocyte mediated cytotoxicity was studied in healthy subjects and patients with systemic lupus erythematosus and metastatic tumours. The purified peripheral blood lymphocytes of healthy subjects exerted a similar cytotoxic activity on allogeneic K-562 and xenogeneic chicken erythrocyte targets in the antibody dependent and spontaneous lymphocyte mediated cytotoxicity tests. There was a stronger correlation between the cytotoxicity measured in the two allogeneic assays than between allogeneic and xenogeneic tests. Allogeneic systems using K-562 targets were more sensitive to changes in cytotoxic activity in systemic lupus erythematosus and metastatic tumours than was the xenogeneic chicken erythrocyte assay.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalActa medica Academiae Scientiarum Hungaricae
Volume34
Issue number3
Publication statusPublished - Dec 1 1977

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ASJC Scopus subject areas

  • Medicine(all)

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