Antibodies against heat shock proteins and cholesterol in HIV infection

G. Füst, Zoltán Beck, D. Bánhegyi, Judit Kocsis, Adrienn Bíró, Z. Prohászka

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

This review summarizes data on the presence and function of different heat shock proteins (Hsp) in the HIV virions and the infected cells. A 60 kD heat shock protein-like molecule is present in the envelope of the human immunodeficiency virus type 1 which can specifically interact with the transmembrane glycoprotein gp41. The role of cholesterol in the so-called cholesterol-rich lipid raft where HIV is budding from the infected cells as well as the consequential insertion of cholesterol into the envelope of HIV virion are also discussed. Natural antibodies against 60 kD (Hsp60) and 70 kD (Hsp70) families of Hsp and cholesterol can be detected in most healthy individuals. HIV infection results in a sharp increase in the serum concentration of anti-Hsp70 and cholesterol antibodies whereas no difference in the concentration of anti-Hsp60 antibodies can be detected. Highly active antiretroviral therapy leads to normalization of the levels of both anti-Hsp70 and anti-cholesterol antibodies.

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalMolecular Immunology
Volume42
Issue number1
DOIs
Publication statusPublished - Jan 2005

Fingerprint

Heat-Shock Proteins
HIV Infections
Cholesterol
Antibodies
HIV
Virion
Anti-Idiotypic Antibodies
Chaperonin 60
Highly Active Antiretroviral Therapy
HIV-1
Glycoproteins
Lipids
Serum

Keywords

  • AIDS
  • Anti-cholesterol antibodies
  • Antibodies
  • Cholesterol
  • Heat shock protein
  • HIV
  • HIV virion
  • Natural antibodies

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Antibodies against heat shock proteins and cholesterol in HIV infection. / Füst, G.; Beck, Zoltán; Bánhegyi, D.; Kocsis, Judit; Bíró, Adrienn; Prohászka, Z.

In: Molecular Immunology, Vol. 42, No. 1, 01.2005, p. 79-85.

Research output: Contribution to journalArticle

Füst, G. ; Beck, Zoltán ; Bánhegyi, D. ; Kocsis, Judit ; Bíró, Adrienn ; Prohászka, Z. / Antibodies against heat shock proteins and cholesterol in HIV infection. In: Molecular Immunology. 2005 ; Vol. 42, No. 1. pp. 79-85.
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