Antibiotics A21459 A and B, New inhibitors of bacterial protein synthesis II. Structure elucidation

P. Ferrari, K. Vékey, M. Galimberti, G. G. Gallo, E. Selva, L. F. Zerilli

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The structures of the antibiotics, active against a few Gram-negative bacteria and Clostridium difficile, were determined on the basis of physicochemical analyses on the intact molecules and on the acid hydrolysate of A21459 A. FAB-MS and 1H and 13C NMR investigations identified the amino acid units and determined their sequence. Antibiotics A21459 A and B are homodetic cyclic peptides constituted by eight amino acid units. They are glycine, methoxytryptophan, tryptophan, cysteine, alanine, sarcosine, dehydroalanine, and α-aminobutyric acid for A21459 A (alanine for A21459 B). Cysteine and alanine condensed to form a thiazole moiety, according to the biosymthesis of thiazole containing antibiotics.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalJournal of Antibiotics
Volume49
Issue number2
Publication statusPublished - Feb 1996

Fingerprint

Protein Synthesis Inhibitors
Bacterial Proteins
Alanine
Thiazoles
Anti-Bacterial Agents
Cysteine
Sarcosine
Aminobutyrates
Amino Acids
Cyclic Peptides
Clostridium difficile
Gram-Negative Bacteria
Tryptophan
Glycine
Acids
A21459 A
A21459 B

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Ferrari, P., Vékey, K., Galimberti, M., Gallo, G. G., Selva, E., & Zerilli, L. F. (1996). Antibiotics A21459 A and B, New inhibitors of bacterial protein synthesis II. Structure elucidation. Journal of Antibiotics, 49(2), 150-154.

Antibiotics A21459 A and B, New inhibitors of bacterial protein synthesis II. Structure elucidation. / Ferrari, P.; Vékey, K.; Galimberti, M.; Gallo, G. G.; Selva, E.; Zerilli, L. F.

In: Journal of Antibiotics, Vol. 49, No. 2, 02.1996, p. 150-154.

Research output: Contribution to journalArticle

Ferrari, P, Vékey, K, Galimberti, M, Gallo, GG, Selva, E & Zerilli, LF 1996, 'Antibiotics A21459 A and B, New inhibitors of bacterial protein synthesis II. Structure elucidation', Journal of Antibiotics, vol. 49, no. 2, pp. 150-154.
Ferrari, P. ; Vékey, K. ; Galimberti, M. ; Gallo, G. G. ; Selva, E. ; Zerilli, L. F. / Antibiotics A21459 A and B, New inhibitors of bacterial protein synthesis II. Structure elucidation. In: Journal of Antibiotics. 1996 ; Vol. 49, No. 2. pp. 150-154.
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