Antibacterial screening of Juncaceae species native to the Carpathian Basin against resistant strains and LC-MS investigation of phenanthrenes responsible for the effect

Barbara Tóth, Erika Liktor-Busa, E. Urbán, Attila Csorba, Gusztáv Jakab, J. Hohmann, Andrea Vasas

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The main objective of this project was to investigate the antibacterial activity of 19 species (Juncus acutus, J. alpinoarticulatus, J. articulatus, J. compressus, J. conglomeratus, J. effusus, J. filiformis, J. gerardii, J. inflexus, J. maritimus, J. monanthos, J. squarrosus, J. tenuis, J. trifidus, Luzula campestris, L. forsteri, L. luzuloides, L. sudetica and L. sylvatica) belonging to the family Juncaceae against methicillin-resistant S. aureus (MRSA), extended-spectrum β-lactamase (ESBL)-producing C. freundii, E. coli, E. cloacae, K. pneumoniae, and multiresistant A. baumannii and P. aeruginosa. Antibacterial susceptibilities were screened for inhibitory zones and MIC values determined by microdilution method. Among the tested extracts (n = 96) 16 extracts prepared from Juncus species and 3 extracts from Luzula species showed mild to strong inhibitory activities against MRSA strains (inhibition zones = 6.7 mm–14.6 mm; MIC values 9.75–156 μg/mL). It can be concluded that Juncus and Luzula species demonstrated promising anti-MRSA effect, and J. maritimus, J. tenuis and J. gerardii considered worthy of activity-guided phytochemical investigations. The main bioactive constituents of Juncaceae species are phenanthrenes. Four phenanthrenes [juncuenin D (1), juncusol (2), dehydrojuncuenin B (3), and jinflexin B (4)] isolated previously from J. inflexus with anti-MRSA activity were investigated by LC-MS in extracts proved to be active in antimicrobial test.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalFitoterapia
Volume115
DOIs
Publication statusPublished - Dec 1 2016

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Phenanthrenes
Methicillin Resistance
Cloaca
Phytochemicals
Pneumonia
Escherichia coli

Keywords

  • Anti-MRSA activity
  • Juncaceae
  • Juncus
  • LC-MS
  • Luzula
  • Phenanthrenes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Antibacterial screening of Juncaceae species native to the Carpathian Basin against resistant strains and LC-MS investigation of phenanthrenes responsible for the effect. / Tóth, Barbara; Liktor-Busa, Erika; Urbán, E.; Csorba, Attila; Jakab, Gusztáv; Hohmann, J.; Vasas, Andrea.

In: Fitoterapia, Vol. 115, 01.12.2016, p. 69-73.

Research output: Contribution to journalArticle

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