Antibacterial properties of compounds isolated from Carpobrotus edulis

A. Martins, A. Vasas, M. Viveiros, J. Molnár, J. Hohmann, L. Amaral

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Several compounds isolated from the plant Carpobrotus edulis were evaluated for their activity against multidrug-resistant (MDR) bacteria and their efflux pump systems. Amongst the compounds isolated, six compounds were tested, namely uvaol, β-amyrin, oleanolic acid, catechin, epicatechin and monogalactosyldiacylglycerol. Oleanolic acid presented high antibacterial activity against a large number of bacterial strains. The triterpene uvaol was the most active compound for modulation of efflux activity by MDR Gram-positive strains.

Original languageEnglish
Pages (from-to)438-444
Number of pages7
JournalInternational Journal of Antimicrobial Agents
Volume37
Issue number5
DOIs
Publication statusPublished - May 1 2011

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Keywords

  • Aizoaceae
  • Carpobrotus edulis
  • Efflux pump inhibition
  • Efflux pumps
  • Enterococcus faecalis
  • Escherichia coli
  • Isolated compounds
  • Multidrug resistance
  • Mycobacterium tuberculosis
  • Salmonella enterica serotype Enteritidis
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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