Antiangiogenic effects of radiotherapy but not initial microvessel density predict survival in inoperable oropharyngeal squamous cell carcinoma

József Lövey, Júlia Lukits, E. Remenár, Krísztina Koronczay, M. Kásler, György Németh, J. Tímár

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To evaluate the predictive value of intratumoral microvessel density (MVD) in patients with locally advanced, primarily inoperable oropharyngeal cancer (OPCC) treated with irradiation alone. Patients and Methods: Tumor samples of 35 patients with OPCC subjected to radiotherapy were taken before and after 20 Gy irradiation. Histological grade, mitotic activity index and MVD of OPCC were determined. Correlations with response and survival were analyzed. Results: Stage and posttreatment MVD decrease showed significant correlation with objective response. Postirradiation MVD decrease correlated significantly with response to irradiation and overall survival, and a trend could be seen for progression-free survival. Conclusion: This study has shown that the change in MVD after irradiation can be an indicator of the success of radiotherapy in locally advanced OPCC, and may serve as a predictive factor thus helping to select patients who could benefit from more aggressive treatment.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalStrahlentherapie und Onkologie
Volume182
Issue number3
DOIs
Publication statusPublished - Mar 2006

Fingerprint

Oropharyngeal Neoplasms
Microvessels
Squamous Cell Carcinoma
Radiotherapy
Survival
Mitotic Index
Disease-Free Survival
Neoplasms

Keywords

  • Angiogenesis
  • Head-and-neck cancer
  • Microvessel density
  • Prediction
  • Radiotherapy
  • Survival

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cancer Research
  • Radiological and Ultrasound Technology

Cite this

Antiangiogenic effects of radiotherapy but not initial microvessel density predict survival in inoperable oropharyngeal squamous cell carcinoma. / Lövey, József; Lukits, Júlia; Remenár, E.; Koronczay, Krísztina; Kásler, M.; Németh, György; Tímár, J.

In: Strahlentherapie und Onkologie, Vol. 182, No. 3, 03.2006, p. 149-156.

Research output: Contribution to journalArticle

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AU - Lövey, József

AU - Lukits, Júlia

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AU - Koronczay, Krísztina

AU - Kásler, M.

AU - Németh, György

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AB - Purpose: To evaluate the predictive value of intratumoral microvessel density (MVD) in patients with locally advanced, primarily inoperable oropharyngeal cancer (OPCC) treated with irradiation alone. Patients and Methods: Tumor samples of 35 patients with OPCC subjected to radiotherapy were taken before and after 20 Gy irradiation. Histological grade, mitotic activity index and MVD of OPCC were determined. Correlations with response and survival were analyzed. Results: Stage and posttreatment MVD decrease showed significant correlation with objective response. Postirradiation MVD decrease correlated significantly with response to irradiation and overall survival, and a trend could be seen for progression-free survival. Conclusion: This study has shown that the change in MVD after irradiation can be an indicator of the success of radiotherapy in locally advanced OPCC, and may serve as a predictive factor thus helping to select patients who could benefit from more aggressive treatment.

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