Antiamnesic effects of D-pipecolic acid and analogues of Pro-Leu-Gly-NH2 in rats

Gábor L. Kovács, Gyula Szabó, Gyula Telegdy, Lajos Baláspiri, Éva Pálos, László Szpornyi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The antiamnesic effects of prolyl-leucyl-glycinamide (PLG) and analogues of this tripeptide were investigated in rats. Retrograde amnesia was induced by electroconvulsive shock treatment and the degree of amnesia was characterized by the attenuation of one-trial learning passive avoidance response. PLG resulted in dose-dependent attenuation of retrograde amnesia. Structural modifications included N-terminal protection, substitution of the C-terminal NH2 group, replacement of the N-terminal amino acid, and replacement of the second amino acid of the tripeptide. Some tripeptides, all of them containing D-pipecolic acid instead of the N-terminal proline, were more effective than PLG. Therefore, D-pipecolic acid, D-pipecolamide and their N-terminally protected analogues were also investigated, and were found to have powerful antiamnesic effects.

Original languageEnglish
Pages (from-to)833-837
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume31
Issue number4
DOIs
Publication statusPublished - Dec 1988

Keywords

  • D-Pipecolic acid
  • Prolyl-leucyl-glycinamide
  • Retrograde amnesia

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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