Anti-psychotic drugs reverse multidrug resistance of tumor cell lines and human AML cells ex-vivo

Diána Szabó, Gábor Szabó, Imre Ocsovszki, Adorján Aszalos, József Molnár

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Anti-psychotic drugs are used in cancer patients undergoing chemotherapy frequently and the concomitantly used drugs may alter the pharmacokinetics of each other. One reason for the alteration of pharmacokinetics may be the modulation of the function of P-glycoprotein, whose efflux pump occurs in resistant cancer cells, in human intestine and in the blood-brain barrier. For this reason we tested the effect of several anti-psychotic drugs on the multidrug-resistant pump, P-glycoprotein. We found that in the MDR gene transfected L121C MDR, L5178 MDR and in the KB-V-1 cells selected for resistance some anti-psychotic drugs block the function of P-glycoprotein. Blood cells of two treatment-resistant leukemic patients also showed increased uptake of daunorubicin if treated ex vivo with the anti-psychotic drugs. Our results suggest that pharmacokinetic studies should be performed prior to concomitant clinical use of such drugs which block P-glycoprotein function. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalCancer Letters
Volume139
Issue number1
DOIs
Publication statusPublished - May 3 1999

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Keywords

  • Amitriptyline
  • Cyclosporin A
  • Desipramine
  • Fluphenazine
  • Haloperidol
  • Imipramine
  • In patients
  • In vitro
  • In vivo
  • Maprotiline
  • Multidrug resistance
  • Reversal
  • Trimipramine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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