Abstract
Background: Although multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in diabetes mellitus, a major cardiovascular risk factor. Therefore, here we investigated if a preparation of different minerals, vitamins, and trace elements (MVT) for human use affects the severity of experimental diabetes. Methods: Two days old neonatal Wistar rats from both genders were injected with 100 mg/kg of streptozotocin or its vehicle to induce diabetes. At week 4, rats were fed with an MVT preparation or vehicle for 8 weeks. Well established diagnostic parameters of diabetes, i.e. fasting blood glucose and oral glucose tolerance test were performed at week 4, 8 and 12. Moreover, serum insulin and blood HbA1c were measured at week 12. Results: An impaired glucose tolerance has been found in streptozotocin-treated rats in both genders at week 4. In males, fasting blood glucose and HbA1c were significantly increased and glucose tolerance and serum insulin was decreased at week 12 in the vehicle-treated diabetic group as compared to the vehicle-treated non-diabetic group. All of the diagnostic parameters of diabetes were significantly improved by MVT treatment in male rats. In females, streptozotocin treatment resulted in a less severe prediabetic-like phenotype as only glucose tolerance and HbA1c were altered by the end of the study in the vehicle-treated diabetic group as compared to the vehicle-treated non-diabetic group. MVT treatment failed to improve the diagnostic parameters of diabetes in female streptozotocin-treated rats.Conclusion: This is the first demonstration that MVT significantly attenuates the progression of diabetes in male rats with chronic experimental diabetes. Moreover, we have confirmed that females are less sensitive to STZ-induced diabetes and MVT preparation did not show protection against prediabetic state. This may suggest a gender difference in the pathogenesis of diabetes.
| Original language | English |
|---|---|
| Article number | 72 |
| Journal | BMC Endocrine Disorders |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Aug 26 2014 |
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Keywords
- Diabetes
- Gender difference
- Minerals
- Multivitamin
- Prevention
- Streptozotocin
- Trace elements
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Medicine(all)
Cite this
Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats : A gender difference. / Sárközy, Márta; Fekete, Veronika; Szucs, Gergo; Török, Szilvia; Szucs, Csilla; Bárkányi, Judit; Varga, Zoltán V.; Földesi, I.; Csonka, C.; Kónya, Csaba; Csont, T.; Ferdinándy, P.
In: BMC Endocrine Disorders, Vol. 14, No. 1, 72, 26.08.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats
T2 - A gender difference
AU - Sárközy, Márta
AU - Fekete, Veronika
AU - Szucs, Gergo
AU - Török, Szilvia
AU - Szucs, Csilla
AU - Bárkányi, Judit
AU - Varga, Zoltán V.
AU - Földesi, I.
AU - Csonka, C.
AU - Kónya, Csaba
AU - Csont, T.
AU - Ferdinándy, P.
PY - 2014/8/26
Y1 - 2014/8/26
N2 - Background: Although multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in diabetes mellitus, a major cardiovascular risk factor. Therefore, here we investigated if a preparation of different minerals, vitamins, and trace elements (MVT) for human use affects the severity of experimental diabetes. Methods: Two days old neonatal Wistar rats from both genders were injected with 100 mg/kg of streptozotocin or its vehicle to induce diabetes. At week 4, rats were fed with an MVT preparation or vehicle for 8 weeks. Well established diagnostic parameters of diabetes, i.e. fasting blood glucose and oral glucose tolerance test were performed at week 4, 8 and 12. Moreover, serum insulin and blood HbA1c were measured at week 12. Results: An impaired glucose tolerance has been found in streptozotocin-treated rats in both genders at week 4. In males, fasting blood glucose and HbA1c were significantly increased and glucose tolerance and serum insulin was decreased at week 12 in the vehicle-treated diabetic group as compared to the vehicle-treated non-diabetic group. All of the diagnostic parameters of diabetes were significantly improved by MVT treatment in male rats. In females, streptozotocin treatment resulted in a less severe prediabetic-like phenotype as only glucose tolerance and HbA1c were altered by the end of the study in the vehicle-treated diabetic group as compared to the vehicle-treated non-diabetic group. MVT treatment failed to improve the diagnostic parameters of diabetes in female streptozotocin-treated rats.Conclusion: This is the first demonstration that MVT significantly attenuates the progression of diabetes in male rats with chronic experimental diabetes. Moreover, we have confirmed that females are less sensitive to STZ-induced diabetes and MVT preparation did not show protection against prediabetic state. This may suggest a gender difference in the pathogenesis of diabetes.
AB - Background: Although multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in diabetes mellitus, a major cardiovascular risk factor. Therefore, here we investigated if a preparation of different minerals, vitamins, and trace elements (MVT) for human use affects the severity of experimental diabetes. Methods: Two days old neonatal Wistar rats from both genders were injected with 100 mg/kg of streptozotocin or its vehicle to induce diabetes. At week 4, rats were fed with an MVT preparation or vehicle for 8 weeks. Well established diagnostic parameters of diabetes, i.e. fasting blood glucose and oral glucose tolerance test were performed at week 4, 8 and 12. Moreover, serum insulin and blood HbA1c were measured at week 12. Results: An impaired glucose tolerance has been found in streptozotocin-treated rats in both genders at week 4. In males, fasting blood glucose and HbA1c were significantly increased and glucose tolerance and serum insulin was decreased at week 12 in the vehicle-treated diabetic group as compared to the vehicle-treated non-diabetic group. All of the diagnostic parameters of diabetes were significantly improved by MVT treatment in male rats. In females, streptozotocin treatment resulted in a less severe prediabetic-like phenotype as only glucose tolerance and HbA1c were altered by the end of the study in the vehicle-treated diabetic group as compared to the vehicle-treated non-diabetic group. MVT treatment failed to improve the diagnostic parameters of diabetes in female streptozotocin-treated rats.Conclusion: This is the first demonstration that MVT significantly attenuates the progression of diabetes in male rats with chronic experimental diabetes. Moreover, we have confirmed that females are less sensitive to STZ-induced diabetes and MVT preparation did not show protection against prediabetic state. This may suggest a gender difference in the pathogenesis of diabetes.
KW - Diabetes
KW - Gender difference
KW - Minerals
KW - Multivitamin
KW - Prevention
KW - Streptozotocin
KW - Trace elements
UR - http://www.scopus.com/inward/record.url?scp=84907915233&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907915233&partnerID=8YFLogxK
U2 - 10.1186/1472-6823-14-72
DO - 10.1186/1472-6823-14-72
M3 - Article
C2 - 25160946
AN - SCOPUS:84907915233
VL - 14
JO - BMC Endocrine Disorders
JF - BMC Endocrine Disorders
SN - 1472-6823
IS - 1
M1 - 72
ER -