Anti-cholesterol antibody levels in hereditary angioedema

L. Varga, Adrienn Bíró, G. Széplaki, Luca Tóth, A. Horváth, G. Füst, H. Farkas

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Hereditary angioedema (HAE) is a rare disorder caused by the deficiency of the C1-inhibitor gene (C1INH) and characterized by recurrent bouts of angioedema. Autoimmune disorders frequently occur in HAE. Previously we found, that danazol has an adverse effect on serum lipid profile: reduced high-density lipoprotein (HDL) and elevated low-density lipoprotein (LDL) cholesterol levels are associated with long-term prophylactic use, whereas total cholesterol levels are unchanged. Our aim was to study the anti-cholesterol antibody (ACHA) production in HAE patients and compare it with those of healthy blood donors, and to investigate the possible associations between ACHA levels and serum lipid profile alterations caused by danazol. Anti-cholesterol IgG levels were measured by ELISA and their correlation with serum concentrations of total cholesterol, HDL, LDL, triglycerides was determined in HAE patients receiving/not receiving danazol. Serum ACHA levels were significantly higher in HAE patients, compared to healthy blood donors (P <0.0001). Longterm danazol prophylaxis had no effect on serum ACHA levels in HAE patients. However, we found a significant, negative correlation between ACHA levels and serum total cholesterol (r = -0.4033, P = 0.0200), LDL (r = -0.4565, P = 0.0076) and triglyceride (r = -0.4230, P = 0.0121) levels only in danazol-treated patients, but not in HAE patients who did not receive long-term prophylaxis. Patients with HAE have higher baseline ACHA levels compared to healthy subjects, and this might reflect polyclonal B-cell activation. The latter would be a potential explanation for the lack of an increased incidence of infectious diseases in HAE patients, but might lead to increased autoimmunity.

Original languageEnglish
Pages (from-to)1377-1383
Number of pages7
JournalJournal of Cellular and Molecular Medicine
Volume11
Issue number6
DOIs
Publication statusPublished - Nov 2007

Fingerprint

Hereditary Angioedemas
Anti-Idiotypic Antibodies
Danazol
Cholesterol
Antibodies
Serum
Blood Donors
Blood
Lipids
Angioedema
HDL Lipoproteins
LDL Lipoproteins
LDL Cholesterol
HDL Cholesterol
Autoimmunity
Triglycerides
Antibody Formation
Communicable Diseases
Immunoglobulin G
Genes

Keywords

  • Anti-cholesterol antibodies (ACHA)
  • Atherosclerosis
  • Cholesterol
  • Hereditary angioedema
  • Humoral immune response

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Anti-cholesterol antibody levels in hereditary angioedema. / Varga, L.; Bíró, Adrienn; Széplaki, G.; Tóth, Luca; Horváth, A.; Füst, G.; Farkas, H.

In: Journal of Cellular and Molecular Medicine, Vol. 11, No. 6, 11.2007, p. 1377-1383.

Research output: Contribution to journalArticle

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