Anti-chlamydial effect of plant peptides

Emese Petra Balogh, Tímea Mosolygó, Hilda Tiricz, Ágnes Míra Szabó, Adrienn Karai, Fanni Kerekes, Dezso P. Virók, Éva Kondorosi, Katalin Burián

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Even in asymptomatic cases of Chlamydia trachomatis infection, the aim of the antibiotic strategy is eradication of the pathogen so as to avoid the severe late sequelae, such as pelvic inflammatory disease, ectopic pregnancy, and tubal infertility. Although first-line antimicrobial agents have been demonstrated to be predominantly successful in the treatment of C. trachomatis infection, treatment failures have been observed in some cases. Rich source of antimicrobial peptides was recently discovered in Medicago species, which act in plants as differentiation factors of the endosymbiotic bacterium partner. Several of these symbiotic plant peptides have proved to be potent killers of various bacteria in vitro. We show here that 7 of 11 peptides tested exhibited antimicrobial activity against C. trachomatis D, and that the killing activity of these peptides is most likely due to their interaction with specific bacterial targets.

Original languageEnglish
Pages (from-to)229-239
Number of pages11
JournalActa microbiologica et immunologica Hungarica
Volume61
Issue number2
DOIs
Publication statusPublished - Jun 1 2014

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Keywords

  • Chlamydia
  • NCR peptide
  • antimicrobial

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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