Lehetöségek az adhezív folyamatok befolyásolására és az antithrombotikus kezelésre integrin kötést gátló tripeptidekkel (Arg-Gly-Asp).

Translated title of the contribution: Anti-adhesive and anti-thrombotic effects of integrin-inhibiting tripeptides (Arg-Gly-Asp)

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The RGD (Arg-Gly-Asp) motif has a widespread distribution in the cellular adhesive structures on platelets, lymphocytes, some viruses and matrix proteins. RGD sequence seems to confer adhesive properties to macromolecular proteins like fibronectin, vitronectin, von Willebrand factor, fibrinogen and many others. So RGD tripeptide and its analogues really deserve to be regarded as general disintegrin sequence. A concise review is given to analyze the most important achievements by using RGD peptides as antiplatelet agents along with an overview of the potential clinical application of the disintegrin peptides in other fields of medicine.

Translated title of the contributionAnti-adhesive and anti-thrombotic effects of integrin-inhibiting tripeptides (Arg-Gly-Asp)
Original languageHungarian
Pages (from-to)2155-2159
Number of pages5
JournalOrvosi hetilap
Volume136
Issue number40
Publication statusPublished - Oct 1 1995

ASJC Scopus subject areas

  • Medicine(all)

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